TGF-beta signaling in tumor suppression and cancer progression.

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The logic of TGFβ signaling (2006, background): “that promote tumor growth [92], invasion [85,86], evasion of”
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer (2010, background): “TGF-b itself is a regulator of many types of physiological and pathophysiological EMT (Derynck et al., 2001; Thiery et al., 2009).”
TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance (2005, unknown): “During tumor progression, production of TGF-β leads to escape from immune surveillance in vivo (Akhurst and Derynck, 2001; Derynck et al., 2001; Siegel et al., 2003).”
The cytoprotective role of the Keap1–Nrf2 pathway (2011, background): “In this way, parallels can be drawn between the action of the Keap1–Nrf2 pathway and TGF-b or NF-jB signalling in cancer, as all three pathways have pleiotropic effects on the tumour phenotype (Derynck et al. 2001; Perkins 2004).”
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. (2005, background): “Members of the transforming growth factor b (TGF-b ) super-family play numerous important functions in diverse developmental processes by regulating proliferation, differentiation, and apoptosis (reviewed in Derynck et al., 2001; Pollard, 2001; Wakeﬁeld et al., 2001).”