Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis

By M. Skobe, T. Hawighorst, D. Jackson, R. Prevo, L. Janes, P. Velasco, L. Riccardi, K. Alitalo, K. Claffey, Michael Detmar. Nature Medicine, 2001

1,749 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/750db9124a0041dd700bc3cd23d55b7acb38a24a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Zena Werb
2. E. Nakasone
3. M. Egeblad
4. K. Alitalo
5. Peter Carmeliet
6. D. Pattabiraman
7. Arthur W. Lambert
8. R. Weinberg

In Oncology

1. Zena Werb
2. M. Egeblad
3. E. Nakasone
4. R. Weinberg
5. K. Alitalo
6. D. Pattabiraman
7. Arthur W. Lambert
8. Peter Carmeliet

In Surgery

1. K. Alitalo
2. R. Weinberg

Citations in the corpus

• EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, positive): “…of lymphatic vessels through the process of lymphangiogenesis (Karaman and Detmar, 2014) – a process that is correlated with disease progression (Skobe et al., 2001) – there is scant evidence for the notion that the draining lymph nodes represent temporary staging areas that enable…”
• Molecular mechanisms of lymphangiogenesis in health and disease. (2002, background): “Indeed, depending on the molecular markers used to label putative lymphatic vessels and the tumor model or type used to study tumor lymphangiogenesis, intratumoral lymphatic vessels were documented in tumor xenografts overexpressing VEGF-C or VEGF-D (Karpanen et al., 2001; Skobe et al., 2001; Stacke”
• Angiogenesis in Cancer (2006, neutral): “…(Andre et al 2000; George et al 2001; Furudoi et al 2002), breast cancer (Kurebayashi et al 1999; Gunningham et al 2000; Kinoshita et al 2001; Skobe et al 2001), lung cancer (Decaussin et al 1999; Niki et al 2000; Kajita et al 2001), head and neck squamous cell carcinoma (O-charoenrat et al…”
• Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. (2002, background): “Their significance was recently highlighted by experiments in which rapid development of lymph node metastasis was achieved in immunodeficient mice that were implanted with transgenically VEGF-C-overexpressing tumors and that developed large peritumoral lymphatic vessels.(6,7,9,10) However, Figure 2”
• Abnormal lymphatic vessel development in neuropilin 2 mutant mice. (2002, background): “VEGFC and VEGFD have also been shown to stimulate metastasis via the lymphatic vessels (Karpanen et al., 2001; Mandriota et al., 2001; Skobe et al., 2001; Stacker et al., 2001).”
• Tumors as organs: complex tissues that interface with the entire organism (2010, positive): “and promote metastasis to lymph nodes (Skobe et al., 2001; Stacker et al., 2001).”