From circuits to behaviour in the amygdala
By P. Janak, K. Tye. Nature, 2015
1,780 citations recorded by the source corpus.
The amygdala has long been associated with emotion and motivation, playing an essential part in processing both fearful and rewarding environmental stimuli. How can a single structure be crucial for such different functions? With recent technological advances that allow for causal investigations of specific neural circuit elements, we can now begin to map the complex anatomical connections of the amygdala onto behavioural function. Understanding how the amygdala contributes to a wide array of behaviours requires the study of distinct amygdala circuits.
Subfields: Cognitive Neuroscience, Social Psychology
View Paper: https://www.semanticscholar.org/paper/74845589853040255e1af7b8414259c185d54f59
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cognitive Neuroscience
In Social Psychology
- Ted G. Dinan
- J. Cryan
- Matthew N Hill
- Arash Afraz
- Colin Klein
- Mehrdad Jazayeri
- Andrew B. Barron
- G. Clarke
Citations in the corpus
- Stress & the gut-brain axis: Regulation by the microbiome (2017, neutral): “Altered amygdalar processes are associated with a variety of neuropsychiatric disorders, ranging from autism spectrum (Schumann and Amaral, 2006; Mosconi et al., 2009) to anxiety disorders (LeDoux, 2007; Janak and Tye, 2015).”
- Insects have the capacity for subjective experience (2016, background): “Although the medial pallium is weakly homologous to the mammalian amygdala, these structures principally possess feedforward circuits that execute nociceptive defensive behaviours (Broglio et al., 2005; Duvarci and Pare, 2014; Janak and Tye, 2015).”
- Navigating the Neural Space in Search of the Neural Code. (2017, positive): “Many advanced optogenetic experiments aim tomaintain perturbations close to the NMOI by targeting specific signaling pathways (Gradinaru et al., 2010; Janak and Tye, 2015; Yizhar et al., 2011).”
- Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration (2017, background): “Structural and functional changes in the amygdala are associated with a variety of neuropsychiatric disorders ranging from autism spectrum (Schumann & Amaral, 2006; Mosconi et al. 2009) to anxiety disorders (Ledoux, 2007; Janak & Tye, 2015).”
- Neurobiological Interactions Between Stress and the Endocannabinoid System (2016, background): “…as the central amygdala (CeA), medial amygdala, bed nucleus of the stria terminalis (BNST), nucleus accumbens, and distinct hypothalamic nuclei such as the lateral, anterior, and dorsomedial hypothalamus (Hermans et al, 2014b; Janak and Tye, 2015; Ulrich-Lai and Herman, 2009; Veinante et al, 2013).”
- Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline (2016, neutral): “Specifically, we discuss recent work on the role of cholinergic signaling in spatial memory, which heavily engages the hippocampus, and in emotionally salient memories, with a focus on studies in the amygdala (Burgess et al., 2002; Janak and Tye, 2015).”