Tumor microenvironmental physiology and its implications for radiation oncology.

By P. Vaupel. Seminars in Radiation Oncology, 2004

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Detection and Characterization of Tumor Hypoxia Using pO2 Histography (2007, neutral): “124, 125, 129, 139).”
Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements☆ (2017, background): “In the context of RT, radioresistance of hypoxic cells confers an increased risk of tumor recurrence and poor prognosis [153,154].”
Hypoxia and cancer (2007, background): “In addition, cells that survive acidosis not only develop a growth advantage but also become more aggressive and invasive [6, 44].”
Hypoxia in cancer: significance and impact on clinical outcome (2007, background): “Very often, tumor microvessels are perfused (at least transiently) by plasma only [8].”
The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression (2019, methodology): “Relationship between mean critical diffusion distances for oxygen (O2, blue curve, circles) and glucose (red curve, diamonds) in breast cancer tissue (for computation of diffusion distances, in vivo data are used; Vaupel 2004).”