Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation.

By R. Ramasamy, S. Vannucci, Shirley Shidu Yan, K. Herold, S. Yan, A. Schmidt. Glycobiology, 2005

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How researchers see this paper

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Diabetic macular edema: pathogenesis and treatment. (2009, background): “Animal studies have shown AGEs to be involved in activation of all these processes.(183,233,276)”
Periodontal disease: associations with diabetes, glycemic control and complications. (2008, background): “These cell types include mononuclear phagocytes , endothelial cells, fibroblasts, smooth muscle cells, lymphocytes, podocytes, and neurons (Brett et al, 1993; Ramasamy et al, 2005).”
Oxidative Stress in Aging Human Skin (2015, background): “Unfortunately though the decreased activity of this enzyme has been reported during aging [281].”
Advanced Glycation End Products and Diabetes Mellitus: Mechanisms and Perspectives (2022, background): “The increased ER stress will cause mitochondrial dysfunction, alter redox homeostasis, play a crucial role in damaging cellular processes and the infrastructure of the cell, and contribute to oxidative stress propagation [2,69,70].”
Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action (2010, background): “be capable of reducing the neurodegeneration associated with the accumulation AGEs during normal [203] and abnormal brain ageing [204].”