Synapse specificity of long-term potentiation breaks down at short distances

By F. Engert, Tobias Bonhoeffer. 1997

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Citations in the corpus

Diffusion-based neuromodulation can eliminate catastrophic forgetting in simple neural networks (2017, background): “Neurotransmitter spillover has been observed in different areas of the brain such as the hippocampus [30,55,56], cerebellum [57], and olfactory bulb [32,58].”
Partial Breakdown of Input Specificity of STDP at Individual Synapses Promotes New Learning (2016, background): “However, in experiments with spike timing-dependent plasticity (STDP), only local changes at the synapses surrounding activated inputs have been reported (Schuman and Madison, 1994; Engert and Bonhoeffer, 1997; Royer and Paré, 2003).”
Spike timing-dependent plasticity: from synapse to perception. (2006, methodology): “Using an elegant local perfusion method that restricted synaptic activation to a small region (Ͻ20 ␮m) of the hippocampal slice culture, Engert and Bonhoeffer (29) have estimated the extent of spread of LTP in the CA1 pyramidal cell.”
Heterosynaptic Plasticity Prevents Runaway Synaptic Dynamics (2013, background): “…of LTP breaks down, and a pairing protocol leads to LTP in a local population of synapses, including those not activated during the induction (Bonhoeffer et al., 1989; Kossel et al., 1990; Engert and Bonhoeffer, 1997), and even synapses at neighboring neurons (Schuman and Madison, 1994).”
Spike Timing Dependent Plasticity: A Consequence of More Fundamental Learning Rules (2010, unknown): “Dendritic excitation may also account for locally spreading heterosynaptic LTP and LTD, in which synaptic activity can cause plasticity at near (Johnston et al., 2003) by synapses (Engert and Bonhoeffer, 1997; Wang et al., 2000b).”
A temporally asymmetric Hebbian rule governing plasticity in the human motor cortex. (2003, background): “This apparent contradiction may be resolved by postulating similar spatial properties of the input-specificity of Hebbian synapses in motor cortex as established in vitro, in organotypical slice cultures of rat hippocampus (Engert and Bonhoeffer 1997).”
Locally dynamic synaptic learning rules in pyramidal neuron dendrites (2007, unknown): “Crosstalk did not perturb input-specificity per se , and therefore differed from the heterosynaptic spread of plasticity 5,31,32,35 .”
NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012, unknown): “Experiments using this approach to induce NMDAR-dependent LTP have shown that LTP can be induced at a single synapse without causing postsynaptic potentiation or depression of neighboring synapses (Matsuzaki et al. 2004; Harvey and Svoboda 2007; but see Engert and Bonhoeffer 1997).”
Synaptic modification by correlated activity: Hebb's postulate revisited. (2001, background): “A closer examination using local perfusion indicated that, in hippocampal slice cultures, LTP can spread to other inputs on the same postsynaptic cell as long as the unstimulated synapses are within∼70 µm of the site of LTP induction (Engert & Bonhoeffer 1997).”
Dendritic excitability and synaptic plasticity. (2008, unknown): “There are some reports, however, showing that input specificity breaks down for synapses that are on the order of tens of microns apart, most likely due to lateral spread inside the dendritic branch of some messenger molecule (200, 277), or due to presynaptically expressed LTP mediated by nonspecifi”
Two opposing plasticity mechanisms pulling a single synapse. (2008, unknown): “[ 2 ]). By contrast, homeostatic synaptic plasticity (HSP) [3‐5]is a negative feedback mechanism (persistent overactivation of the neuron results in compensatory weakening of synapses and vice versa) operating at a substantially slower timescale on the order of hours to days.”