Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells1

By D. I. Gabrilovich, M. P. Velders, E. Sotomayor, W. Kast. Journal of Immunology, 2001

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Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. (2006, background): “Although Gr-1 immature myeloid cells from the spleens of tumorbearing mice have been shown to suppress the proliferation of CD4 and CD8 T cells (18, 46), the sorted Gr-1 single positive cells of Percoll fraction 2 did not suppress HA-mediated proliferation of CD4 (Fig.”
Adipose Tissue in Obesity-Related Inflammation and Insulin Resistance: Cells, Cytokines, and Chemokines (2013, unknown): “These cells are also defined by their immature state of macrocytic/monocytic, granulocytic/neutrophilic, and dendritic cell precursors and are characterized by the increased production of extracellular degradative enzymes, cytokines, and reactive oxygen and nitrogen species [108].”
MyD88-dependent expansion of an immature GR-1+CD11b+ population induces T cell suppression and Th2 polarization in sepsis (2007, background): “The answer may simply be that these GR-1+ cells express very little MHC class II, whereas they retain relatively high levels of MHC class I expression (11).”
Dynamics of the immune reaction to pancreatic cancer from inception to invasion. (2007, background): “Gr-1 and CD11b, are found within the graft microenvironment and can suppress specific T-cell responses in vitro (16, 43, 44).”