Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABAA receptors

By B. Stell, S. Brickley, Chih-Yung Tang, M. Farrant, István Módy. Proceedings of the National Academy of Sciences of the United States of America, 2003

835 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Social Psychology

View Paper: https://www.semanticscholar.org/paper/739782833a5af8f1804d27d8d89e8d8d6eb14921

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. István Módy
2. Richard W. Olsen
3. S. Brickley
4. W. Sieghart
5. Daniel A. Bromberg
6. G. Westbrook
7. AeSoon Bensen
8. Linda Overstreet-Wadiche

In Molecular Biology

1. István Módy
2. Richard W. Olsen
3. S. Brickley
4. W. Sieghart

In Social Psychology

1. Richard W. Olsen
2. W. Sieghart
3. István Módy

Citations in the corpus

• Neurosteroids: endogenous regulators of the GABAA receptor (2005, background): “In mouse DGCs and CGCs, low 'physiological' concentrations (10–100 nM) of 3α,5α-THDOC selectively enhance the tonic conductance, with little or no effect on the phasic conductanc”
• Extrasynaptic GABAA receptors: Their function in the CNS and implications for disease (2012, background): “…ambient GABA levels alone, with GABA uptake blockers, will induce an anesthesia-like state (Katayama et al., 2007) and neurosteroids (which are brain-synthesized metabolites of ovarian and adrenal cortical steroid hormones) act as anesthetics through an action on d-GABAARs (Stell et al., 2003).”
• GABAA Receptors: Subtypes Provide Diversity of Function and Pharmacology (2008, positive): “…appear to reflect those of a native subtype found in CA1 pyramidal neurons (that are enriched in both a5 and b3 subunits) and are distinct from receptors in dentate gyrus granule cells (Burgard et al., 1996; Sur et al., 1998; McClellan and Twyman, 1999; Stell et al., 2003; Caraiscos et al., 2004).”
• Contributions of the GABAA Receptor α6 Subunit to Phasic and Tonic Inhibition Revealed by a Naturally Occurring Polymorphism in the α6 Gene (2006, background): “Our interpretation that subunit-containing GABARs are responsible for tonic current is also consistent with recently reported findings that CGCs in subunit knock-out mice lack tonic current (Stell et al., 2003).”
• International Union of Pharmacology. LXX. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update (2008, background): “…to reflect those of a native subtype found in CA1 pyramidal neurons, cells enriched in both (cid:2) 5 and (cid:7) 3 subunits, and distinct from receptors in dentate gyrus granule cells (Burgard et al., 1996; Sur et al., 1998; McClennan and Twyman, 1999; Stell et al., 2003; Caraiscos et al., 2004).”
• GABAergic signaling to newborn neurons in dentate gyrus. (2005, background): “mediated primarily by extrasynaptic receptors containing δ subunits (Stell et al., 2003)”
• Expression of Distinct α Subunits of GABAA Receptor Regulates Inhibitory Synaptic Strength (2004, positive): “␣4 and ␣6 subunits in combination with ␦ subunit are responsible for tonic activation of perisynaptic and extrasynaptic receptor in hippocampal and cerebellar granule neurons, respectively (Stell et al. 2003; Sundstrom-Poromaa et al. 2002; Wei et al. 2003).”