Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR

By Khalid Al-Nedawi, B. Meehan, R. Kerbel, A. Allison, J. Rak. Proceedings of the National Academy of Sciences of the United States of America, 2009

667 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/737dad4784d6881552ffe930bf35fa43709c798f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Raghu Kalluri
2. T. Whiteside
3. G. Raposo
4. Marina Colombo
5. C. Théry
6. X. Breakefield
7. Alissa M. Weaver
8. Sybren L. N. Maas

In Immunology and Allergy

1. T. Whiteside
2. G. Raposo
3. Raghu Kalluri

In Molecular Biology

1. Raghu Kalluri
2. G. Raposo
3. C. Théry
4. Marina Colombo
5. X. Breakefield
6. T. Whiteside
7. Alissa M. Weaver
8. Christoph Kahlert

Citations in the corpus

• Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche. (2011, background): “Moreover, tumor-derived MVs may transport to neighboring cells, the products of oncogenes (11).”
• Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, background): “Finally, tumor-derived EVs also display proangiogenic activities, mediated by interaction with endothelial cells (Al-Nedawi et al. 2009, Sheldon et al. 2010).”
• The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses (2020, background): “EGFR activates the autocrine vascular growth factor receptor (VEGF)/VEGFR-2 pathway in endothelial cells that supports angiogenesis (177).”
• Exosome-Based Cell-Cell Communication in the Tumor Microenvironment (2018, background): “Additionally, skin cancer-derived exosomes can promote angiogenesis by delivering Epidermal Growth Factor receptor (EGFR) (Al-Nedawi et al., 2009) and miR-9 to ECs (Gajos-Michniewicz et al., 2014).”
• Tumor-derived exosomes and their role in cancer progression (2016, background): “They carry surface components that enable contact with endothelial cells and facilitate exosome entry into vessels and tissues [80, 82].”
• Extracellular Vesicles: Unique Intercellular Delivery Vehicles. (2017, background): “In culture, after uptake of glioblastoma-derived EVs, levels of vascular endothelial growth factor (VEGF) increase in endothelial cells and activate the VEGF-receptor 2 in an autocrine manner [116].”
• Exosomes in Tumor Microenvironment Influence Cancer Progression and Metastasis (2013, background): “Furthermore, cancer cells transfer membrane-bound EGFR to endothelial cells via exosomes [38].”