BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.

By E. Patton, H. Widlund, J. Kutok, K. Kopani, J. Amatruda, R. Murphey, S. Berghmans, Elizabeth A. Mayhall, D. Traver, C. Fletcher and 6 more. Current Biology, 2005

692 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/736d7c705e563fb52a79281d838e100dad9e374c

How researchers see this paper

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In Molecular Biology

1. W. Mooi
2. D. Peeper
3. C. Michaloglou
4. R. DePinho
5. T. Kuilman
6. J. Campisi
7. Manuel Serrano

In Oncology

1. D. Peeper
2. R. DePinho
3. T. Kuilman
4. J. Campisi

Citations in the corpus

• BRafV600E cooperates with Pten silencing to elicit metastatic melanoma (2009, background): “Data presented here are consistent with effects of transgenic overexpression of BRAF V600E in zebrafish, which leads to the development of 'fish nevi”
• The essence of senescence. (2010, background): “The studies on senescent nevi are consistent with earlier observations that a mutant BRAF transgene in the melanocytic compartment induces the formation of nevus-like lesions in zebrafish (Patton et al. 2005).”