Structural determinants of the cellular localization and shuttling of TDP-43

By Y. Ayala, P. Zago, A. D’Ambrogio, Ya-fei Xu, L. Petrucelli, E. Buratti, Francisco E. Baralle. Journal of Cell Science, 2008

627 citations recorded by the source corpus.

Subfields: Genetics, Neurology

View Paper: https://www.semanticscholar.org/paper/72d09041f0fcc3c43e2e8823842ed0d6a78ec40a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. D. Cleveland
2. M. Polymenidou
3. Aaron Gitler
4. J. Shorter
5. Oliver D. King
6. Francisco E. Baralle

In Neurology

1. M. Polymenidou
2. D. Cleveland
3. Dennis W. Dickson
4. V. Lee
5. John Q. Trojanowski
6. Oliver D. King
7. Christian Haass
8. J. Shorter

Citations in the corpus

• Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration (2011, result): “TDP43 mislocalization Although TDP43 is predominantly nuclear, interspecies heterokaryon assays have shown that it shuttles between nuclear and cytoplasmic compartments, which is consistent with studies that have been able to detect low levels of cytoplasmic TDP43 in normal cell”
• ALS‐associated fused in sarcoma (FUS) mutations disrupt Transportin‐mediated nuclear import (2010, background): “Both FUS and TDP-43 are DNA- and RNA-binding proteins that shuttle continuously between the nucleus and cytoplasm (Zinszner et al, 1997b; Ayala et al, 2008) and are involved in multiple steps of gene expression, such as transcriptional regulation, pre-mRNA splicing and microRNA processing (Buratti…”
• Converging mechanisms in ALS and FTD: Disrupted RNA and protein homeostasis (2013, positive): “Cytoplasmic Functions of TDP-43 and FUS/TLS TDP-43 and FUS/TLS in Cytoplasmic RNA Granules TDP-43 and FUS/TLS shuttle from the nucleus to the cytosol (Ayala et al., 2008; Zinszner et al., 1997), where they have been associated with cytoplasmic RNA granules that contain nontranslating mRNAs.”
• Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity (2009, background): “Substituting the charged amino acid (lysine or arginine) to alanine results in cytoplasmic expression (17).”
• Stress granules as crucibles of ALS pathogenesis (2013, methodology): “Follow this and additional works at: https://escholarship.umassmed.edu/wellstone_pubs Part of the Cell Biology Commons, Developmental Biology Commons, Molecular Biology Commons,”
• TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. (2010, background): “(I) Both TDP-43 and FUS/TLS shuttle between the nucleus and the cytosol (134,142) and (J) are incorporated in SGs where they form complexes with mRNAs and other RNA binding proteins (82,166,190,201–204).”