Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
By Yong-Jie Zhang, Ya-fei Xu, C. Cook, Tania F. Gendron, Paul Roettges, C. Link, Wen‐lang Lin, Jimei Tong, M. Castanedes-Casey, Peter E. A. Ash and 7 more. Proceedings of the National Academy of Sciences of the United States of America, 2009
608 citations recorded by the source corpus.
Subfields: Genetics, Neurology
View Paper: https://www.semanticscholar.org/paper/988e8417765977db34f8e5d883bf864716890161
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In Genetics
In Neurology
- M. Polymenidou
- D. Cleveland
- V. Lee
- John Q. Trojanowski
- Ann C. McKee
- Dennis W. Dickson
- D. Selkoe
- Leonidas Stefanis
Citations in the corpus
- Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue (2010, background): “increase in formation of cytoplasmic inclusions [9,12].”
- TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration (2009, background): “These data indicate that Prp-TDP43A315T mice develop C-terminal fragmentation of TDP-43 at an early stage before the onset of gait abnormalities or significant brain pathology, and are consistent with the idea that C-terminal fragments could play a direct role in TDP-43 associated neurodegeneration ”
- TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. (2010, background): “Curiously, in contrast to observations in patients (6,7,46) and in cell culture (204,237,238,240), where 25 kDa CTF is mainly cytoplasmic, the same fragment in transgenic mice was present solely in the nucleus where it formed intranuclear inclusions (222).”
- Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration (2011, background): “Indeed, phosphorylation is not an absolute requirement for TDP43 cleavage, aggregation or toxicity in cell culture system”