Differential Production of IL-12, IFN-α, and IFN-γ by Mouse Dendritic Cell Subsets1

By H. Hochrein, K. Shortman, D. Vremec, B. Scott, P. Hertzog, Meredith O'Keeffe. Journal of Immunology, 2001

486 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/723ba43612b9cbbc131ef6a7ed22e046908804b8

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Citations in the corpus

Steady-state and inflammatory dendritic-cell development (2007, background): “The CD8 + and CD8 − cDCs differ in immune functions, including cytokine productio”
Viral infection switches non-plasmacytoid dendritic cells into high interferon producers (2003, methodology): “Electroporation with poly(I:C) allowed conventional splenic dendritic cells to produce levels of IFN-α much greater than previously reporte”
Quantitative proteomics reveals subset-specific viral recognition in dendritic cells. (2010, background): “This TLR9 and TLR3 ligand combination is a stimulus known to induce high amounts of cytokines from CD8a+ cDCs (Hochrein et al., 2001).”
Adhesion mechanisms regulating the migration of monocytes (2004, background): “Pulmonary DCs are considered to be of myeloid origin because they express high levels of the α M -integrin (CD11b), intermediate levels of the α X -integrin (CD11c) and are CD8α −”
Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens (2010, background): “Mouse CD8+ DCs are renowned for their ability to produce IL-12p70 (Reis e Sousa et al., 1997; Maldonado-López et al., 1999; Hochrein et al., 2001) and induce the Th1 cytokines IL-2 and IFN- (Maldonado-López et al., 1999; Pulendran et al., 1999; Skokos and Nussenzweig, 2007; Soares et al., 2007),…”
Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology (2001, background): “Among different mouse DC subsets, spleen CD8α + DCs can produce type I IFN in response to a combination of CpG and poly(I·C”
Cutting Edge: Type I IFNs Provide a Third Signal to CD8 T Cells to Stimulate Clonal Expansion and Differentiation1 (2005, background): “The CD8 subset of murine DC that most effectively presents Ag to CD8 T cells by cross-priming (20) can produce IL-12 and IFN- in response to activating stimuli such as TLR ligands (21, 22).”
Mouse and human dendritic cell subtypes (2002, background): “The three DC subtypes found in uninfected laboratory mouse spleen differ in their capacity to produce cytokines when stimulated under conditions designed to induce a maximal respons”