Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylases.

By N. Mosammaparast, Yang Shi. Annual Review of Biochemistry, 2010

608 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2e81f3e421541bc563fb25dede933d96a6a7fe01

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Citations in the corpus

Single-cell RNA-seq and computational analysis using temporal mixture modelling resolves Th1/Tfh fate bifurcation in malaria (2017, background): “Many other epigenetic regulators also contribute to the management of hematopoietic HOX gene expression (39).”
Cancer Genetics and Epigenetics: Two Sides of the Same Coin? (2012, background): “Two distinct classes of HDMs have been defined based on their mechanism of action (Mosammaparast and Shi, 2010).”
The JmjC domain‐containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene (2012, background): “Although histone methylation had long been thought to be an irreversible chromatin mark, the discovery of histone demethylases has changed this view.(1,2) These are two classes of histone lysine demethylases, the amine oxidase-related enzymes and the Jumonji C-terminal domain (JmjC)-containing enzym”
A double take on bivalent promoters. (2013, background): “Under these circumstances, H3K4me3 demethylases of the Jarid1/ KDM5 class (Mosammaparast and Shi 2010) can compete with H3K4me3 deposition, leading to removal of H3K4me3 from at least one copy of H3 at the TSS-associated nucleosome.”
Cancer epigenetics: from mechanism to therapy. (2012, background): “The initial notion that histone lysine methylation was a highly stable, nondynamic modification has now been irrefutably overturned by the identification of two classes of lysine demethylases (Mosammaparast and Shi, 2010).”