SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells

By Ryuji Hamamoto, Yoichi Furukawa, M. Morita, Y. Iimura, F. P. Silva, Meihua Li, Ryuichiro Yagyu, Yusuke Nakamura. 2004

748 citations recorded by the source corpus.

Subfields: Molecular Biology

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In Molecular Biology

1. Ryuji Hamamoto
2. Yusuke Nakamura
3. N. Dohmae
4. Takehiro Suzuki
5. Makoto Nakakido
6. G. Toyokawa
7. S. Hayami
8. Lianhua Piao

Citations in the corpus

• SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells (2015, methodology): “Many reports have indicated that dysregulation of protein lysine methyltransferases and protein lysine demethylases has important roles in human tumorigenesis [32-37].”
• RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation. (2012, background): “We previously showed that some histone methyltransferases (HMTs) play vital roles in human cancer pathogenesis [22,34–36].”
• Critical roles of non-histone protein lysine methylation in human tumorigenesis (2015, background): “The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.”
• Cancer epigenetics reaches mainstream oncology (2011, background): “SMYD3, another H3K4 HMT, is frequently upregulated in colorectal and hepatocellular carcinoma cell lines, where it enhances cell growth and promotes transformatio”
• Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. (2007, background): “Several human enzymes that catalyze methylation on histone H3 lysine 4 (H3K4me), including MLL and SMYD3, are altered in a variety of cancer types (Ayton and Cleary, 2001; Hamamoto et al., 2004).”
• Enhanced methyltransferase activity of SMYD3 by the cleavage of its N-terminal region in human cancer cells (2008, methodology): “Preparation of C-terminal FLAG-tagged SMYD3 was described previously (Hamamoto et al., 2004).”
• Late Cornified Envelope Group I, a Novel Target of p53, Regulates PRMT5 Activity (2014, methodology): “HEK293T cells were transfected with HA-Mock (empty vector of pCAGGSnHC) or HALCE1F (pCAGGSnHC-LCE1F) using FuGENE6.”
• PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP (2015, methodology): “Accumulated evidence has indicated that methylation of arginine and lysine residues plays an important role in the regulation of many biological processes like phosphorylation does, and its deregulation is almost certainly involved in human tumorigenesis [14, 35-37].”
• Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression. (2012, methodology): “293T cells were transfected with FLAG-PCNA (WT) or FLAG-PCNA (K248A) andHA-SETD8 (1-352) expression vectors.”
• A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5′ flanking region of SMYD3 is a risk factor for human cancers (2005, background): “We previously showed that SMYD3 functions as a specific histone H3 Lys4 di- and trimethyltransferase in the presence of heat-shock protein 90&alpha”