CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

By Y. Belkaid, C. Piccirillo, S. Mendez, E. Shevach, D. Sacks. Nature, 2002

1,931 citations recorded by the source corpus.

Subfields: Immunology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/70bc3dd408c696d10383d02ba60f6094e3f229c7

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In Immunology

1. Shimon Sakaguchi
2. J. Bluestone
3. A. O’Garra
4. Q. Tang
5. L. Walker
6. Tomoyuki Yamaguchi
7. P. Vieira
8. E. Shevach

In Public Health, Environmental and Occupational Health

1. Shimon Sakaguchi

Citations in the corpus

• Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells (2004, background): “Other papers report the presence of receptors for inflammatory chemokines (CCR2, CCR4, CCR5, and CCR8) and increased levels of adhesion molecules (CD54 and LFA-1) on regulatory subsets (5, 13, 15, 16), suggesting that these cells are able to enter inflamed tissues and might act directly at sites of ”
• Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo (2003, background): “The accumulation of CD25 cells at the site of longterm pathogen retention in a recent study suggests that this paradigm could hold true for foreign as well as self-antigens (27).”
• Regulatory T cells and immune tolerance. (2008, background): “Yet, complete eradication of microbes via Treg depletion might hamper the development of effective immunological memory for the microbes, thus impairing the secondary immune responses upon reinfection (Belkaid et al., 2002).”
• Foxp3 Expressing CD4+CD25high Regulatory T Cells Are Overrepresented in Human Metastatic Melanoma Lymph Nodes and Inhibit the Function of Infiltrating T Cells1 (2004, background): “It has been recently shown in a murine model of Leishmania major infection that CD4 CD25 Treg control the persistence of the parasite by suppressing, through both IL-10-dependent and IL-10-independent mechanisms, the ability of CD4 CD25 effector T cells to eliminate the parasite (64).”
• T-cell quality in memory and protection: implications for vaccine design (2008, background): “Of note, clearance of the parasites results in reduced immunity and protectio”
• CD4+CD25+ T Cells Regulate Virus-specific Primary and Memory CD8+ T Cell Responses (2003, background): “The initial focus was on organ-specific autoimmunity, but immunopathological reactions to foreign exogenous antigens, including those expressed by microorganisms, are also influenced by Treg (3, 5, 6, 21).”