Two to tango: regulation of Mammalian iron metabolism.

By Matthias W. Hentze, M. Muckenthaler, B. Galy, C. Camaschella. Cell, 2010

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How researchers see this paper

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Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease (2015, background): “To maintain adequate and safe amounts of iron, cells require the coordination of a wide variety of genes, which tightly control both intracellular (reviewed in [2,3]) and systemic (reviewed in [4]) iron metabolism.”
Iron metabolism and iron disorders revisited in the hepcidin era (2020, positive): “Binding to its ubiquitous receptor TFR1, transferrin delivers iron to cells through the wellknown endosomal cycle.(1) This function is crucial not only for erythropoiesis, but also for muscle(4) and for B- and Tlymphocytes, as highlighted by a TFR1 homozygous mutation that causes combined immunodefi”
HSPB1 as a Novel Regulator of Ferroptotic Cancer Cell Death (2015, background): “Iron is a trace element essential for fundamental metabolic processes and cell survival, but its excessive accumulation causes cell death (11, 33).”
Systemic iron homeostasis. (2013, background): “The complementary but largely separate subject of cellular iron regulation was recently reviewed elsewhere (109, 157).”
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (2012, neutral): “could originate from the lack of IRP1 binding to its target mRNAs due to an iron-replete state of the cultured cells (Hentze et al., 2010) and/or from inefficient crosslinking when bound to its targets.”