Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

By Lida Katsimpardi, N. Litterman, Pamela A. Schein, Christine M. Miller, F. Loffredo, G. Wojtkiewicz, J. Chen, Richard T. Lee, A. Wagers, L. Rubin. 2014

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Human Hippocampal Neurogenesis Persists throughout Aging (2018, neutral): “, 2007; Warner-Schmidt and Duman, 2007) and blood-born factors (Katsimpardi et al., 2014) sustaining angiogenesis and cellular plasticity may decline with aging.”
A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance and healthspan (2015, background): “One of the proteins that has been implicated in muscle and brain regeneration, and which may contribute to regenerative effects in multiple systems, is GDF11 (Katsimpardi et al., 2014; Sinha et al., 2014).”
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies (2019, positive): “Recent heterochronic parabiosis experiments demonstrated that introduction of young blood in old mice led to increased neurogenesis and dendritic spine density, and improved agerelated cognitive impairment, (Katsimpardi et al., 2014; Villeda et al., 2014).”
Mechanisms of Vascular Aging (2018, background): “ochronic parabiosis, which involves surgically connecting the circulatory system of a young and an aged mouse.(221)”
The blood-brain barrier. (2015, background): “Recently, systemic proteins have been implicated in regulating neurogenesis differently in youth and during aging (Villeda et al. 2011, 2014; Katsimpardi et al. 2014); however, it remains unclear whether this is because of specific transport, localized permeability of the BBB, or nonspecific passive”