Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function.

By D. Basile, D. Donohoe, Kelly Roethe, J. Osborn. AJP - Renal Physiology, 2001

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Ischemic acute renal failure: an inflammatory disease? (2004, background): “In addition, following prolonged ischemia (60 minutes) in the rat, peritubular capillaries suffer permanent damage [9].”
Recent advances in the pathophysiology of ischemic acute renal failure. (2003, background): “Basile and colleagues (22) have found reductions in the number of microvessels in the inner stripe of the outer medulla at 4, 8, and 40 wk after a prolonged period (60 min) of ischemia in the rat.”
Progression of Chronic Kidney Disease: The Role of Blood Pressure Control, Proteinuria, and Angiotensin-Converting Enzyme Inhibition: A Patient-Level Meta-Analysis (2003, result): “The higher risk for kidney disease progression at current systolic blood pressures less than 110 mm Hg is consistent with animal studies and clinical experience that lower systemic blood pressure may reduce kidney perfusion and decrease kidney function (30, 31).”
Pathophysiology of Acute Kidney Injury (2012, neutral): “The renal expression of TGF-β and its cognate receptors are elevated transiently and return to control levels within approximately 4 weeks.”
Chronic Kidney Disease after Acute Kidney Injury: A Systematic Review and Meta-analysis (2011, background): “, CKD) and may also result in damage to non-renal organs.(4,5) Moreover, the proportion of patients surviving after AKI has also been increasing over time.”