CD40L stabilizes arterial thrombi by a β3 integrin–dependent mechanism

By P. Andre, K. S. Prasad, Cécile V. Denis, Ming He, Jessie M. Papalia, Richard O. Hynes, D. Phillips, Denisa D. Wagner. Nature Medicine, 2002

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Cytokines in atherosclerosis: pathogenic and regulatory pathways. (2006, background): “Although it may also be shed from stimulated lymphocytes, it is estimated that 95% of circulating CD40L is derived from platelets (19).”
Platelets in atherothrombosis (2002, background): “Stability of the aggregates is as important as the rate of growth in determining whether a thrombus will occlude an artery, and recent findings have shown that CD40 ligand expressed on the membrane of activated platelets is involved in this by binding to α IIb β 3 (ref”
The growing complexity of platelet aggregation. (2007, background): “The exodomains of various platelet surface proteins, including P-selectin,89 CD40L,90 GPIb,91 GPV,92 GPVI,93 and Sema4D,68 are also shed from the surface of platelets with evidence that the soluble form of CD40L promotes thrombus stability by engaging integrin IIb 3.(94)”
The interactions between inflammation and coagulation (2005, background): “This protein then induces tissue factor synthesis (Pendurthi et al, 1997; Miller et al, 1998) and increases inflammatory cytokines, such as IL-6 and IL-8 (Henn et al, 1998; André et al, 2002).”