Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks.

By Brian Magnuson, B. Ekim, D. Fingar. Biochemical Journal, 2012

980 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6e9cce5d01364ba73c98e639f5823550f4dabccf

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In Molecular Biology

1. D. Fruman
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4. Honyin Chiu
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Citations in the corpus

• The PI3K pathway in human disease (2017, positive): “…S6 kinase-1 (S6K1) contributes to metabolic reprogramming by increasing glycolysis and protein, lipid, and nucleotide biosynthesis (Figure 2) (Magnuson et al., 2012). mTORC1 also initiates powerful negative feedback regulation of growth factor receptor signaling, such that inhibition of…”