Natural innate and adaptive immunity to cancer.

By M. Vesely, M. Kershaw, Robert Schreiber, M. Smyth. Annual Review of Immunology, 2011

2,028 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/6e774d4428c8ed6ad1b31a780628bb0466e46017

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Citations in the corpus

Exosomes and their roles in immune regulation and cancer. (2015, background): “In cancer, complex networks are mediated by tumour cells or pro-inflammatory cell constituents, to facilitate immunomodulation and result in the repression of adaptive immunity against cancer cells [54–56].”
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity (2015, background): “…1259 Likewise, mRNA levels of Ifit1 and Ifit2, two type I IFN-stimulated genes (ISGs), were also elevated in Ptgs2 / tumors (Figure 2D), indicative of enhanced type I interferon (IFN-a/b) signaling, which is central to immune-mediated tumor control (Gajewski et al., 2013; Vesely et al., 2011).”
Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. (2013, background): “The observation that cancer develops more frequently and more aggressively in immunodeficient, as opposed to immunocompetent, mice (Vesely et al., 2011) is paralleled by epidemiological studies showing that transplant recipients (which are subjected to chronic pharmacological immunosuppression)…”
New insights into cancer immunoediting and its three component phases — elimination, equilibrium and escape (2014, positive): “Here the role of host effector molecules, such as IFN-g, perforin, Fas/FasL, and TRAIL; recognition molecules such as NKG2D; and an intact lymphocyte compartment in protective anti-tumour immunity, are well recognized [5,6,17,18] (Figure 2).”
Consensus guidelines for the detection of immunogenic cell death (2014, background): “In this experimental setup, bona fide ICD inducers mediate optimal therapeutic effects in immunocompetent, but not in immunodeficient, mice.(34,41,95,119,233) Importantly, this latter approach is suitable to validate the results of vaccination experiments but cannot be employed alone to determine th”
Pattern recognition receptors in health and diseases (2021, background): “Innate immunity not only plays a role in controlling the infection and spread of pathogens in the early stage of infection but also plays an important role in initiating and regulating adaptive immunity.(12,307) Innate immune cells produce different types of cytokines through signal transduction ini”
The extracellular matrix modulates the hallmarks of cancer (2014, positive): “However, T-cell activity can also be impeded by the ECM through the impairment of antigen presentation by APCs [101].”
NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control (2018, background): “NK cells contribute to anti-tumor immunity in mice and are associated with good prognosis in human cancer patients (Palucka and Coussens, 2016; Vesely et al., 2011).”