Loss of Osteocyte Integrity in Association with Microdamage and Bone Remodeling After Fatigue In Vivo

By O. Verborgt, G. Gibson, M. Schaffler. Journal of Bone and Mineral Research, 2000

738 citations recorded by the source corpus.

Subfields: Molecular Biology, Orthopedics and Sports Medicine, Surgery

View Paper: https://www.semanticscholar.org/paper/6e6996f84c5635c4e5e819d0310299744ebde3cb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Orthopedics and Sports Medicine

In Surgery

S. Manolagas

Citations in the corpus

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015, background): “Osteocyte apoptosis has been shown to act as a chemotactic signal for local osteoclast recruitment [70, 150, 152, 190, 191].”
From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. (2010, background): “Osteocyte death may disrupt the signals necessary for microdamage repair (38) and also lead to long-term changes in bone hydration, as will be discussed in Section X.”
Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes (2013, background): “apoptosis, which may induce osteoclastic resorption and microcrack repair [92].”
Impact of Dental Implant Surface Modifications on Osseointegration (2016, background): “However, stability declines in the first weeks of bone healing due to compression necrosis of neighboring bone and subsequent bone remodeling, a process that has been previously described as implant stability dip (Figure 1) [17, 18].”
Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. (2000, background): “It appears that the bone matrix contains signals regulating the activity of the osteoclasts (108).”
The aging of Wolff's "law": ontogeny and responses to mechanical loading in cortical bone. (2004, background): “The density of lacunae for osteocytes decreases with age in human cortical bone, and as the number of osteocytes decrease, microcracks accumulate and gradually weaken the bone (Vashishth et al., 2000) and may also lead to osteocyte apoptosis (Verborgt et al., 2000).”
Nature’s hierarchical materials (2007, background): “From the observed strong spatial correlation between microdamage, controlled osteocyte death and subsequent remodeling events [301] it is concluded that microscopic cracks disrupt the network of osteocytes resulting in cell death.”