Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

By S. Peleg, F. Sananbenesi, A. Zovoilis, S. Burkhardt, Sanaz Bahari‐Javan, R. Agís‐Balboa, Perla Cota, Jessica L. Wittnam, A. Gogol-Doering, L. Opitz and 6 more. Science, 2010

934 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/33cc04c07a52dcc86198bb1eb33bf2e91d155551

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. R. Stilling
4. Andrea A. Baccarelli
5. Andrew E. Teschendorff
6. Linda Partridge
7. Steve Horvath
8. Manuel Serrano

In Neurology

1. E. Verdin
2. Guido Kroemer
3. Linda Partridge
4. John C. Newman

Citations in the corpus

• DNA damage and its links to neurodegeneration (2014, neutral): “In fact, a number of studies have reported age-associated changes in the epigenome (Krishnan et al., 2011; Peleg et al., 2010; Vijg and Suh, 2013), although precisely what fraction of these changes is a result of DNA damage remains unclear.”
• DNA methylation aging clocks: challenges and recommendations (2019, background): “Additionally, aging in a mouse brain leads to altered hippocampal chromatin plasticity with deregulation of histone H4 lysine 12 (H4K12) acetylation [144], as well as histone variant H2A.”
• The hallmarks of aging. (2013, background): “in mice (Peleg et al., 2010), indicating that reversion of epigenetic changes may have neuroprotective effects.”
• β-Hydroxybutyrate (2017, positive): “Age-related impairments in learning and memory in wild-type mice are associated with alterations in histone acetylation (98), and treatment with HDAC inhibitors improves memory performance in both young and aged mice (42, 98).”
• Early remodeling of the neocortex upon episodic memory encoding (2014, neutral): “member? Curr Opin Neurobiol 17(3):381–386.”
• Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences (2010, methodology): “Individuals and groups not affiliated with the Galaxy team have used Galaxy to perform many different types of genomic research, including investigations of epigenomics [23], chromatin profiling [24], transcriptional enhancers [25], and genome-environment interactions [26].”
• Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020, background): “CHIP can interact with heat shock protein 70 (Hsp70) and induces ubiquitination of tau [170].”
• Epigenetics and aging (2016, background): “Restoration of H4 K12 acetylation recovered both gene expression and learning behavior in aged mice, signifying the critical role of this histone acetylation in aged mice brains (107).”
• Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis (2014, background): “…processes is based on the idea that these molecules do not simply alter acetylation levels at random genomic loci but rather support a given cell’s own regulatory program or facilitate it in cases where it has gone out of balance (McQuown & Wood 2011; Peleg et al. 2010; Stilling & Fischer 2011).”