Molecular portraits of human breast tumours

By Charles M. Perou, T. Sørlie, Michael B. Eisen, M. Rijn, S. Jeffrey, Christian A. Rees, Jonathan R. Pollack, D. Ross, H. Johnsen, L. Akslen and 8 more. Nature, 2000

16,216 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6e436b11eab90258229643cd47861f430f00080c

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In Molecular Biology

Citations in the corpus

Candidate-gene approaches for studying complex genetic traits: practical considerations (2002, background): “For example, by examining expression studies of tumour tissue, investigators have identified genes that might be important in the pathology of certain cancer”
Global gene profiling in human endometrium during the window of implantation. (2002, background): “developing rat kidney (24)] and breast cancer biopsies (25).”
Expression of luminal and basal cytokeratins in human breast carcinoma (2004, background): “Recent cDNA gene expression analysis and TMA immunohistochemical studies have proposed two distinguishable groups with luminal and basal phenotypes that have different cytogenetic alterations and protein expression patterns [6,46].”
Triple-negative breast cancer--current status and future directions. (2009, background): “[8] have demonstrated that high-throughout gene expression analysis carries the potential to capture the heterogeneity of the disease and distinguish BC subclasses solely on the basis of differences regarding their gene expression profile.”
Obesity and adverse breast cancer risk and outcome: mechanistic insights and strategies for intervention (2017, background): “This subset of cancers has a more aggressive phenotype and more often has a luminal B than luminal A gene expression profile.(57) In summary, a large body of evidence indicates that, although obesity is inversely associated with receptorpositive breast cancer development before menopause, it is a ri”
AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective (2010, neutral): “2000 David Botstein showed diversity in the gene expression patterns by breast cancer tissues (228).”
Strategies for subtypes—dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011 (2011, background): “Analysis of gene expression arrays has resulted in the recognition of several fundamentally different subtypes of breast cancer [1].”
Breast Cancer Molecular Subtypes Respond Differently to Preoperative Chemotherapy (2005, methodology): “Molecular classification n [% (95% CI)] n [% (95% CI)] Luminal A/B subtype 28 [93% (78-99)] 2 [7% (1-22)] Normal breast like 10 [100% (29-100)] 0 [0% (0-31)]”
Statistical Significance of Clustering for High-Dimension, Low–Sample Size Data (2008, background): “Some important applications of clustering in cancer genomics have been described by Weinstein et al. (1997), Eisen, Spellman, Brown, and Botstein (1998), Perou et al. (2000), Cai et al. (2004), and Meyerson and Hayes (2005).”
ONCOMINE: a cancer microarray database and integrated data-mining platform. (2004, neutral): “potential, and patient survival [1–24].”