Translation of research evidence from animals to humans.

By D. Hackam, Donald A. Redelmeier. Journal of the American Medical Association (JAMA), 2006

695 citations recorded by the source corpus.

Subfields: Public Health, Environmental and Occupational Health, Small Animals, Statistics and Probability

View Paper: https://www.semanticscholar.org/paper/6e311bd87b03e946557690b9c59270b03da20655

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In Public Health, Environmental and Occupational Health

In Small Animals

In Statistics and Probability

Citations in the corpus

Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research (2010, neutral): “[22] It is unlikely that this issue is confined to clinical research.[2-14,16-20]”
Can Animal Models of Disease Reliably Inform Human Studies? (2010, background): “In a review of animal studies published in seven leading scientific journals of high impact, about one-third of the studies translated at the level of human randomised trials, and one-tenth of the interventions, were subsequently approved for use in patients [1].”
Reproducibility in Science: Improving the Standard for Basic and Preclinical Research (2015, neutral): “clinical research is poorly predictive of ultimate success in the clinic.(14,15) And it is observational research that both attracts”
An open investigation of the reproducibility of cancer biology research (2014, neutral): “Reproducing prior results is challenging because of insufficient, incomplete, or inaccurate reporting of methodologies ( Hess, 2011 ; Prinz et al., 2011 ; Steward et al., 2012 ; Hackam and Redelmeier, 2006 ; Landis et al., 2011 ).”
The ARRIVE guidelines 2.0: updated guidelines for reporting animal research (2020, background): “…suggests that scientific publications often lack key information and that there continues to be considerable scope for improvement (McCance, 1995, Hackam & Redelmeier, 2006, Kilkenny et al. 2009, Macleod et al. 2009, Rice et al. 2009, van der Worp et al. 2010, Glasziou et al. 2014, Macleod et…”
Caring for Critically Ill Patients with the ABCDEF Bundle: Results of the ICU Liberation Collaborative in Over 15,000 Adults (2019, methodology): “When translating animal models to human studies, the most consistent predictor of reproducibility is the dose-response effect of an intervention (54).”
Limitations of Animal Studies for Predicting Toxicity in Clinical Trials (2019, background): “A 2006 review of 76 animal studies, for example, found that approximately 20% were contradicted in humans and only 37% were ever replicated in humans (10).”
Biology-inspired Microphysiological System Approaches to Solve the Prediction Dilemma of Substance Testing (2016, neutral): “…last few decades of research and development have shown clearly that data from animal studies are often poorly indicative of the human situation (Hackam and Redelmeier, 2006; ALTEX 33(3), 2016274 rent human in vitro tests and the human body have not improved attrition rates in clinical trials…”