Regulation of microRNA biogenesis

By Minju Ha, Narry Kim. Nature reviews. Molecular cell biology, 2014

5,124 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6d74d8ca8e35317d50f1816fdaeca1077106e8a6

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Citations in the corpus

An overview of microRNAs: Biology, functions, therapeutics, and analysis methods (2018, methodology): “In addition, multiple regulatory mechanisms influence the accumulation and activity of both Microprocessor and Dicer (Ha & Kim, 2014).”
mirDIP 4.1—integrative database of human microRNA target predictions (2017, background): “This gives miRNAs the capacity to regulate most protein-coding transcripts (5). miRNAs are involved in diverse biological processes, including development, cell growth and metabolism (2).”
Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease (2019, methodology): “The synthesis of miRNAs is a multistep process [reviewed in (Bartel, 2018; Ha and Kim, 2014; Treiber et al., 2019)].”
Metazoan MicroRNAs (2018, background): “Once the loci have been transcribed, diverse regulatory factors (often with additional, previously established cellular functions) influence the stability or processing of individual hairpins (Ha and Kim, 2014; Du et al., 2015; Treiber et al., 2017).”
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “This cleavage event generates an intermediate that is debranched before the hairpin structure is formed (98).”
Tools for Sequence-Based miRNA Target Prediction: What to Choose? (2016, background): “The mature single-stranded miRNA acts as a post-transcriptional regulator binding to the mRNA in a complementary base-pairing manner to prevent the translation of this mRNA target [7].”
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018, background): “In most cases, miRNAs interact with the 3 UTR of target mRNAs to suppress expression (14).”
MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer (2015, background): “Other small RNAs in animals include silencing RNAs (siRNAs), PIWI-interacting RNAs (piRNAs), which are typical of germinal cells [22], and non-coding mitochondrial RNAs (ncmRNAs) [23].”
miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis (2020, background): “In those situations, where the passenger strand is not degraded and both get incorporated into the miRISC complex, the mature miRNA in the guide strand will be the dominant one [21,22].”