Retrograde Viral Delivery of IGF-1 Prolongs Survival in a Mouse ALS Model

By B. Kaspar, J. Lladó, N. Sherkat, Jeffrey D. Rothstein, Fred H. Gage. Science, 2003

882 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/6d73cd2af3059848260227060019ddcd5f4eeecf

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Citations in the corpus

β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression (2005, background): “Initiating drug treatment in this animal model around the time of clinical disease onset at, for example, loss of strength, most closely matches the use of human therapy, and could be more therapeutically relevan”
Current hypotheses for the underlying biology of amyotrophic lateral sclerosis (2009, background): “In addition to VEGF, insulin-like growth factor-1 and glial cell line–derived neurotrophic factor have been reported to delay disease onset and progression in SOD1 mice.(37,38) Although preclinical studies elucidate possible pathogenic pathways and therapeutic options, human trials represent the bes”
Molecular biology of amyotrophic lateral sclerosis: insights from genetics (2006, methodology): “For example, insulin-like growth factor extended survival in the G93A-SOD1 mice when expressed from the type 2 serotype of adeno-associated virus that, in turn, had been carried to the motor neuron by retrograde axonal transport after intramuscular injectio”
Intravascular AAV9 preferentially targets neonatal-neurons and adult-astrocytes in CNS (2008, background): “Gene therapy has been proposed as a means of crossing the BB”
A designer AAV variant permits efficient retrograde access to projection neurons (2016, background): “…al., 2002), rAAVs have afforded some degree of retrograde access to projection neurons in select circuits (Castle et al., 2014; Hollis et al., 2008; Kaspar et al., 2002, 2003; Rothermel et al., 2013; Taymans et al., 2007; Towne et al., 2010), but their natural propensity for retrograde transport…”
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer’s disease (2009, background): “Indeed, growth factor–mediated prevention of neuronal loss in transection models has predicted protection from disease-specific mechanisms in other model”
VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model (2004, methodology): “When injecting a similar amount of a rabies-G pseudotyped EIAV vector expressing glial-cell-line-derived neurotrophic factor (GDNF)—which has been previously reported to delay motor neuron loss in ALS mic”