A novel class of small RNAs in mouse spermatogenic cells.

By Shane T Grivna, Ergin Beyret, Zhong Wang, Haifan Lin. Genes & Development, 2006

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Small noncoding RNAs, including small interfering RNAs (siRNAs) and micro RNAs (miRNAs) of approximately 21 nucleotides (nt) in length, have emerged as potent regulators of gene expression at both transcriptional and post-transcriptional levels in diverse organisms. Here we report the identification of a novel class of small RNAs in the mouse male germline termed piwi-interacting RNAs (piRNAs). piRNAs are approximately 30 nt in length. They are expressed during spermatogenesis, mostly in spermatids. piRNAs are associated with MIWI, a spermatogenesis-specific PIWI subfamily member of the Argonaute protein family, and depend on MIWI for their biogenesis and/or stability. Furthermore, a subpopulation of piRNAs are associated with polysomes, suggesting their potential role in translational regulation.

Subfields: Cancer Research, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/6d345dca6a85ac8fcf8bcca8a2f64213c19d4699

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Citations in the corpus

Distinguishing protein-coding and noncoding genes in the human genome (2007, result): “This is in contrast to piRNAs in adult testis of other mammals, which are depleted of repeat sequences and have no known function (Aravin et al. 2006; Girard et al. 2006; Grivna et al. 2006; Lau et al. 2006; Watanabe et al. 2006).”
Epigenetic reprogramming and small RNA silencing of transposable elements in pollen (2009, neutral): “piRNAs arise from repetitive DNA in a Dicer-independent mechanism (Aravin et al., 2007; Grivna et al., 2006; Lau et al., 2006).”
Transposable elements and the epigenetic regulation of the genome (2007, background): “Piwi proteins bind special small RNAs (termed piRNAs) that are larger (26–30 nucleotides) than most small RNA”
MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. (2007, background): “…others identified small RNA binding partners for Piwi proteins in the male germline, designated as piRNAs (Piwi-interacting RNAs) (Aravin et al., 2006; Girard et al., 2006; Grivna et al., 2006; Lau et al., 2006; Watanabe et al., 2006). piRNAs show distinctive localization patterns in the genome.”
piRNABank: a web resource on classified and clustered Piwi-interacting RNAs (2007, background): “The large-scale sequencing of piRNAs from rat, mouse and human testes by diﬀerent experimental groups have yielded a large number of piRNA sequences, which have been reported in the NCBI nucleotide sequence database (4,7,8) and Supplementary Data in the published literature (5,6).”