Detailed identification of plasma proteins adsorbed on copolymer nanoparticles.

By T. Cedervall, Iseult Lynch, M. Foy, T. Berggård, S. Donnelly, G. Cagney, S. Linse, Kenneth A. Dawson. Angewandte Chemie, 2007

825 citations recorded by the source corpus.

Subfields: Hematology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6d23490da7d4919d354c156c4f9f4628a4d19198

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles. (2008, positive): “Interestingly, TEM images and examination of the number of cytosol-localized particles per μm 3 obtained from the serum-containing condition showed similar trends, suggesting that the differences in particle behaviour are not mediated by differentially adsorbed serum protein”
The evolution of the protein corona around nanoparticles: a test study. (2011, background): “This region normally contains a high concentration of apolipoprotein A-I for nanoparticles that have been incubated in human plasma.(1,4,5,13) 27 Apolipoprotein A-I is still detected in the region marked by arrow 1 in Figure 1c even following incubation in cytosolic fluid.”
Effects of cell culture media on the dynamic formation of protein-nanoparticle complexes and influence on the cellular response. (2010, background): “molecular weight protein do not show particular changes over time.(32,33,38) 40 This suggests that this lat-”
Colloidal stability of silver nanoparticles in biologically relevant conditions (2011, background): “Both citrate-capped and BSA-capped AgNPs were selected, since it has been shown that NPs in real biological systems dynamically adsorb and desorb a significant protein corona in vivo ( Cedervall et al. 2007a ).”
Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? (2010, neutral): “Cedervall et al. (2007) demonstrated that many different plasma proteins adsorb on nanoparticles spontaneously, and that the surface chemistry of the nanoparticles in growth media/plasma is not the same as the originally synthesized materials.”
Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle (2013, background): “Overall, the NP-PC can influence the biological reactivity of the NP [1,2].”