A subset of dopamine neurons signals reward for odour memory in Drosophila

By Chang Liu, P. Plaçais, Nobuhiro Yamagata, B. Pfeiffer, Yoshinori Aso, Anja B. Friedrich, Igor Siwanowicz, Gerald M. Rubin, T. Préat, Hiromu Tanimoto. 2012

574 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Genetics, Insect Science, Neuroscience

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Citations in the corpus

Genetic dissection of mutual interference between two consecutive learning tasks in Drosophila (2022, background): “, 2018) or an appetitive learning task (Liu et al., 2012; Perisse et al., 2013; Pribbenow et al., 2022), which was less similar to the target task.”
Dopaminergic neurons write and update memories with cell-type-specific rules (2016, methodology): “…et al., 2004; Blum et al., 2009; Krashes et al., 2009; Claridge-Chang et al., 2009; Aso et al., 2010; Sejourne et al., 2011; Trannoy et al., 2011; Liu et al., 2012; Burke et al., 2012; Aso et al., 2012; Placais et al., 2013; Pai et al., 2013, Aso et al., 2014b; Lin et al., 2014; Bouzaiane et…”
Coordinated and Compartmentalized Neuromodulation Shapes Sensory Processing in Drosophila (2015, positive): “…sugar feeding activated the γ 4 and γ 5 DANs, in accord with their established role in driving the formation of appetitive olfactory associations (Liu et al., 2012; Yamagata et al., 2015; Waddell, 2013), we observed that sucrose ingestion also inhibited the γ 2 and γ 3 DANs (Figure 2B; Movie S1;…”
Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, methodology): “…associative memory Recent studies of dopamine signaling have implicated distinct sites of memory formation within the MB lobes (summarized in Figure 1A) (Schroll et al., 2006; Claridge-Chang et al., 2009; Aso et al., 2010, 2012; Burke et al., 2012; Liu et al., 2012; Perisse et al., 2013).”
The neuronal architecture of the mushroom body provides a logic for associative learning (2014, methodology): “In classical learning paradigms, different DAN types respond to different unconditioned stimuli (US) (Riemensperger et al., 2005; Mao and Davis, 2009; Burke et al., 2012; Liu et al., 2012).”
The Drosophila Mushroom Body: From Architecture to Algorithm in a Learning Circuit. (2020, background): “Acetylcholine is excitatory, while glutamate is likely inhibitory at most synapses in the central nervous system of adult flies (Liu & Wilson 2013).”
Pain-relief learning in flies, rats, and man: basic research and applied perspectives (2014, background): “distinct from those mediating punishment (Schwaerzel et al. 2003; Burke et al. 2012; Liu et al. 2012), such that distinct sets of Kenyon cell output synapses are likely to be modulated to accommodate conditioned approach.”
Drosophila Learn Opposing Components of a Compound Food Stimulus (2014, background): “learning and others for aversive learning [3, 5–9].”
Distinct dopamine receptor pathways underlie the temporal sensitivity of associative learning (2019, background): “Aversive electric shock and sugar rewards evoke distributed patterns of activity across the DAN population (Burke et al., 2012; Cohn et al., 2015; Liu et al., 2012; Mao and Davis, 2009), implying that these naturalistic reinforcers likewise instruct coordinated bidirectional plasticity across differ”
Do the right thing: neural network mechanisms of memory formation, expression and update in Drosophila (2018, background): “The presynaptic terminals of different subsets of dopaminergic neurons (DANs), encoding positive or negative valence, occupy distinct, nonoverlapping compartments of the mushroom body neuropil which are precisely matched by the dendritic fields of discrete MBONs (Figure 1) [16,18,19,22,23,34 ,35,36]”
Heterosynaptic plasticity underlies aversive olfactory learning in Drosophila (2015, unknown): “…to train an animal by substituting US delivery with direct activation of DANs (Aso et al., 2010; Burke et al., 2012; Claridge-Chang et al., 2009; Liu et al., 2012; Schwaerzel et al., 2003), and the axonal projections of DANs responsible for appetitive and aversive memory are segregated in the…”
Dopamine Neurons Mediate Learning and Forgetting through Bidirectional Modulation of a Memory Trace (2018, unknown): “, 2014a), many of which respond to either rewarding or punishing stimuli and are necessary and sufficient, as a US, for memory formation (Mao and Davis, 2009; Schwaerzel et al., 2003; Claridge-Chang et al., 2009; Liu et al., 2012; Lin et al., 2014).”
Modelling learning and memory in Drosophila to understand Intellectual Disabilities. (2020, unknown): “This process is believed to form the neural basis of olfactory associative learning (Heisenberg, 2003; Schwaerzel et al., 2003; Kim et al., 2007; Burke et al., 2012; Liu et al., 2012; Qin et al., 2012; Cohn et al., 2015; Hige et al., 2015; Owald and Waddell, 2015; Rohwedder et al., 2016; Kaun and Ro”
Neuronal mechanisms underlying innate and learned olfactory processing in Drosophila. (2019, background): “Many DANs respond 206 specifically to punishment (electric shock) or reward (sugar) [63], and blocking DANs 207 prevents memory formation [64-66], while artificial activation of DANs alone during odor 208 stimulus is sufficient to induce memory formation [67-73] (see Table 1).”