Noise in Gene Expression: Origins, Consequences, and Control

By J. Raser, E. O’Shea. Science, 2005

1,838 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/6cf147927d1c82a0e4c040363bceb795c0cc8101

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In Molecular Biology

Citations in the corpus

Stochastic modelling for quantitative description of heterogeneous biological systems (2009, background): “; biological systems have also developed strategies for both exploitin”
Roles for microRNAs in conferring robustness to biological processes. (2012, neutral): “Intrinsic noise refers to variation arising from stochastic events, including promoter binding, mRNA decay, translation, and protein degradation (Raser and O’Shea, 2005).”
Sequence signatures and mRNA concentration can explain two-thirds of protein abundance variation in a human cell line (2010, background): “The remaining, unexplained protein abundance variation may also be explained by gene expression noise (Raser and O’Shea, 2005) and by sequence features that are not included in this study.”
Network resilience (2020, background): “presence of stochastic fluctuations, which are induced by extrinsic and intrinsic noises [345].”
Systems medicine: the future of medical genomics and healthcare (2009, neutral): “driving the behavior of biological systems [146,147].”
Comparison and evaluation of statistical error models for scRNA-seq (2021, background): “The presence of intrinsic noise has been extensively characterized and is an inevitable consequence of the gene regulatory process [26, 27, 49, 50].”
mRNA-Seq whole-transcriptome analysis of a single cell (2009, background): “It is also possible that for some genes with low expression, their expression can be stochastically on or off in single cell, and these genes were probably not expressed in the individual cell analyzed by our mRNA-Seq assa”
Stability of Genetic Networks With SUM Regulatory Logic: Lur'e System and LMI Approach (2006, background): “All cell components also exhibit intracellular noises owing to random births and deaths of individual molecules, and extracellular noises owing to environment fluctuations [7]–[9], [18], [19], [26].”
Canalization of development by microRNAs (2006, background): “Noise-buffering mechanisms exist in order to confer robustness to genetic pathways (reviewed in refs”