Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving

By K. L. Conrad, Kuei Yuan Tseng, Jamie L. Uejima, Jeremy M. Reimers, Li-jun Heng, Y. Shaham, M. Marinelli, M. Wolf. Nature, 2008

740 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6cef29dd0a137a31439f265b48e36b84d9b94d02

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Nora D. Volkow
2. G. Koob
3. E. Nestler
4. R. Malenka
5. Peter W. Kalivas
6. C. Lüscher
7. S. Russo
8. J. Steketee

In Molecular Biology

1. Nora D. Volkow
2. G. Koob
3. Peter W. Kalivas
4. R. Malenka
5. E. Nestler
6. S. Russo
7. J. Steketee
8. C. Lüscher

Citations in the corpus

• Drug Wanting: Behavioral Sensitization and Relapse to Drug-Seeking Behavior (2011, background): “It is noteworthy that, like sensitization, conditioned cues reduce AMPA receptor surface expression 24 h after exposure to these cues (Conrad et al., 2008).”
• The Addicted Synapse: Mechanisms of Synaptic and Structural Plasticity in Nucleus Accumbens (2010, background): “) Behaviorally, incubation of cocaine craving is seen during withdrawal from cocaine self-administration; this is characterized by a gradual and progressive increase in cocaine seeking and susceptibility to relapse, which may require these changes in the stoichiometry of synaptic AMPA receptors [42,”
• Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling (2011, background): “In fact, pharmacological or synaptic activation of mGluR1 in slices from cocaine-treated mice quickly removes GluA2-lacking AMPARs and replaces them with GluA2-containing ones, leading to an overall depression of synaptic transmission (Bellone and Lüscher, 2005, 2006).”
• Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli (2011, neutral): “…may also contribute to the delayed yet persistent synaptic adaptations observed at excitatory synapses in the NAc (Kauer and Malenka, 2007; Conrad et al., 2008; Kalivas, 2009; Chen et al., 2010; Wolf, 2010), changes that are dependent on the initial synaptic adaptations in midbrain DA…”
• The Brain on Drugs: From Reward to Addiction. (2015, background): “, 2009; Malenka and Nicoll, 1997), which are subsequently unsilenced through the insertion of AMPAR lacking GluA2 (Box 3)(Conrad et al., 2008; Dobi et al., 2011).”
• Neurobiology of the incubation of drug craving (2011, neutral): “saline) and tested for cocaine seeking after 1 or 45 withdrawal days [90].”
• Neurocircuitry of Addiction (2009, background): “…ratio of glutamate-1 receptors (GluR1) has been observed 21 days after the last injection of cocaine, suggesting a slowly developing redistribution of AMPA receptors to the surface of nucleus accumbens neurons, particularly in those lacking GluR2 (Boudreau and Wolf, 2005; Conrad et al, 2008).”
• Synaptic and Behavioral Profile of Multiple Glutamatergic Inputs to the Nucleus Accumbens (2012, neutral): “There is an emerging consensus that cocaine-induced changes in synaptic strength can involve calcium permeable AMPARs, which have been linked to drug craving, but only if cocaine is self-administered over many days (Conrad et al., 2008; Wolf and Tseng, 2012).”