Untangling the Genetic Basis of Fibrolytic Specialization by Lachnospiraceae and Ruminococcaceae in Diverse Gut Communities

By A. Biddle, Lucy C. Stewart, J. Blanchard, S. Leschine. 2013

925 citations recorded by the source corpus.

The Lachnospiraceae and Ruminococcaceae are two of the most abundant families from the order Clostridiales found in the mammalian gut environment, and have been associated with the maintenance of gut health. While they are both diverse groups, they share a common role as active plant degraders. By comparing the genomes of the Lachnospiraceae and Ruminococcaceae with the Clostridiaceae, a more commonly free-living group, we identify key carbohydrate-active enzymes, sugar transport mechanisms, and metabolic pathways that distinguish these two commensal groups as specialists for the degradation of complex plant material.

Subfields: Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/6cc8ceaa99fa15b03afaa78fad8216e7fb251f6a

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In Molecular Biology

In Nutrition and Dietetics

M. Collado

Citations in the corpus

Blautia—a new functional genus with potential probiotic properties? (2021, result): “According to the results of previous 16S rRNA studies, Firmicutes is one of the core phyla of the intestinal microbiota of humans and other vertebrates, and Lachnospiraceae and Ruminococcaceae are the most abundant families of this phylum, accounting for 50% and 30% of the total intestinal microbiot”
The Controversial Role of Human Gut Lachnospiraceae (2020, background): “In fact, their ability to use complex plant material and transport degradation products of various sizes and compositions was confirmed by metagenomics studies [21].”
Interaction between chicken intestinal microbiota and protein digestion (2016, background): “…of the family Ruminococcaceae are able to attack cellulose and other highly recalcitrant polysaccharides more efficiently than the members of Lachnospiraceae, but the Lachnospiraceae are able to readily degrade less recalcitrant non-starch polysaccharides and starch (Biddle et al., 2013).”
Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota (2023, background): “Firmicutes species, including Lactobacillaceae, Ruminococcaceae and Lachnospiraceae, are able to break down complex polysaccharides and other sugars through hydrolysis, resulting in the production of butyrate and other SCFAs [69,70].”