The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys

By M. Stremlau, C. M. Owens, M. Perron, Michael Kiessling, P. Autissier, J. Sodroski. Nature, 2004

1,933 citations recorded by the source corpus.

Subfields: Immunology, Virology

View Paper: https://www.semanticscholar.org/paper/6cc67a47cc0c738cf7eca2465a3bb30f20969acd

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In Immunology

1. R. Randall
2. A. García‐Sastre
3. Graciana Diez-Roux
4. Charles M. Rice
5. Eran Bacharach
6. S. Goodbourn
7. G. Meroni

In Virology

1. Yong‐Zhen Zhang
2. Charles M. Rice
3. Beatrice H. Hahn
4. Paul M. Sharp
5. Edward C. Holmes

Citations in the corpus

• Retroviral Restriction Factor TRIM5α Is a Trimer (2005, background): “TRIM5 is a constitutively expressed cytoplasmic protein that allows the cells of primates to resist infection by particular retroviruses, including human immunodeficiency virus type 1 (HIV-1) (10, 14, 25, 31, 32, 37).”
• Selecton 2007: advanced models for detecting positive and purifying selection using a Bayesian inference approach (2007, background): “TRIM5a restriction probably acts on the viral capsid ( 44 ), although direct physical interaction between TRIM5a and the capsid proteins has not yet been demonstrated.”
• Virus Entry: Open Sesame (2006, neutral): “In another example, the so-called Lv1 (or Ref1) restriction that prevents HIV-1 replication in Old World monkeys ismediated by a homo-oligomeric protein called Trim 5a (Stremlau et al., 2004; Towers, 2005).”
• The Evolution and Emergence of RNA Viruses (2009, background): “In an analogous manner, the TRIM5 gene is able to induce to a cytoplasmic barrier to some retroviral infections, restricting HIV infection in Old World monkeys (Stremlau et al. 2004).”
• TRIM/RBCC, a novel class of ‘single protein RING finger’ E3 ubiquitin ligases (2005, background): “TRIM5 Restriction of HIV-1 infection (78) TRIM7/GNIP Activation of glycogenin self-glucosylation (89) TRIM8/GERP Inhibition of SOCS-1-dependent IFNg-mediated transcription (26)”
• Origins of HIV and the AIDS pandemic. (2011, background): “…which interferes with reverse transcription (Sheehy et al. 2002); (2) TRIM5a (tripartite motif 5a protein), which interferes with viral uncoating (Stremlau et al. 2004); and (3) tetherin (also termed BST-2 and CD317) which inhibits the budding and release of virions from infected cells (Neil et…”
• Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by RIG-I (2009, background): “TRIM5a has been extensively studied as a host restriction factor for HIV-1 infection (Stremlau et al., 2004).”