Gene–environment interactions in human diseases

By D. Hunter. Nature reviews genetics, 2005

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Genetic Mapping in Human Disease (2008, background): “The decades-old problem of defining interaction ( 21 , 22) is even more prominent in the GWAS era.”
GENETICS AND PATHOGENESIS OF INFLAMMATORY BOWEL DISEASE (2016, background): “Nonetheless, the potential environmental exposure identified from these studies (if available), can be used as a screening tool for further validation (79).”
Gene-environment interplay and psychopathology: multiple varieties but real effects. (2006, background): “…population stratification, inadequate sample sizes, multiple testing, and low prior probabilities of association (Cardon & Palmer, 2003; Colhoun et al., 2003; Hunter 2005; Lohmueller, Pearce, Pike, Lander, & Hirschhorn, 2003; Sullivan, Eaves, Kendler, & Neale, 2001; van den Oord & Sullivan, 2003).”
Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression (2009, methodology): “Strengths of the analysis reported herein include: (1) use of the same variable definitions (ie, the number of S alleles and an ordinal measure of life events) and analytic approach that was used in the original report in order to provide a valid test of replication; (2) inclusion of primary data fr”
Gene-Environment-Wide Association Studies: Emerging Approaches (2010, neutral): “For example, G×E interactions might allow the effects of the components of a complex mixture, such as air pollution, to be dissecte”