Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering.

By Soo‐Hong Lee, Heungsoo Shin. Advanced Drug Delivery Reviews, 2007

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Controlled drug delivery in tissue engineering. (2008, background): “Thus, it has been soon realized that by integrating controlled release strategies within scaffoldingmaterials may lead to novel multifunctional platforms able to control and guide the tissue regeneration process [18–22].”
Mineralized structures in nature: Examples and inspirations for the design of new composite materials and biomaterials (2010, background): “These processed materials are viable under in vitro and in vivo conditions, allowing the integration of the scaffold with the living tissues [80].”
Recent advances in bone tissue engineering scaffolds (2012, background): “For example, BMP-2 induces osteoinductivity in a dose dependent manner: μg quantities act as differentiation stimuli for direct endochondral ossification and chondrogenesis of MSCs, while ng levels recruit stem cells through chemotaxis [51][74] [75].”
Nanoscale hydroxyapatite particles for bone tissue engineering. (2011, background): “The study of CaPs is a specific area in nanotechnology, which may be applied readily in the repair of hard and soft skeletal tissues [48–50].”
Strategies for Controlled Delivery of Growth Factors and Cells for Bone Regeneration (2012, background): “Therefore, a critical component in designing a controlled delivery system is selection of the appropriate single or combination of growth factors for maximized tissue repair [19].”