Genome Mining for Novel Natural Product Discovery

By G. Challis. 2008

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The Natural Product Domain Seeker NaPDoS: A Phylogeny Based Bioinformatic Tool to Classify Secondary Metabolite Gene Diversity (2012, background): “This revelation has led to an explosion of interest in genome mining as an approach to natural product discovery [3,4,5,6,7,8].”
Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. (2014, background): “Connecting these natural products to the genes that encode them is revolutionizing their study, enabling genome sequence data to guide the discovery of new molecules (Bergmann et al., 2007; Challis, 2008; Franke et al., 2012; Freeman et al., 2012; Kersten et al., 2011; Laureti et al., 2011; Lautru e”
Antibiotics and the gut microbiota. (2014, unknown): “Coloniof exploratory bioinformatics tools and expression screening techniques, previously studied strains have yielded new antibacterial molecules of substantial interest (10, 11); prior screening efforts failed to identify these molecules, in large part because they were not expressed under routine”