CD8+ T cell effector mechanisms in resistance to infection.

By J. Harty, A. Tvinnereim, D. White. Annual Review of Immunology, 2000

846 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/6c63fa477375522e4256c0a6f1be939499ee3d7c

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In Immunology

Citations in the corpus

Adoptive-cell-transfer therapy for the treatment of patients with cancer (2003, neutral): “5 8 MART-1, gp100 PR (8) Vitiligo subcutaneous”
Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells (2010, background): “During this process, the differentiating cells induce the expression of effector proteins such as the cytokine IFNg, the pore-forming protein perforin, and a family of serine esterases known collectively as granzymes (Cruz-Guilloty et al., 2009; Harty et al., 2000).”
Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation (2012, background): “CD8 memory T cells are specialized in the generation of large quantities of proinflammatory, immunoregulatory, and microbicidal mediators upon activation and are further able to rapidly eliminate infected target cells (2).”
Size-Dependent Immunogenicity: Therapeutic and Protective Properties of Nano-Vaccines against Tumors1 (2004, background): “Usually, and in contrast to natural infections, vaccines with adjuvants able to induce high CD8 T cell responses do not generate high Ab levels and vice versa (1, 7).”
T-cell-antigen recognition and the immunological synapse (2003, background): “Whereas the contribution of the CTL compartment to the adaptive cytokine response is increasingly eviden”
Programmed contraction of CD8+ T cells after infection (2002, background): “Expansion is required to produce sufficient effector CD8 + T cells, which use cell-mediated cytolysis and cytokine production to defend the host against rapidly multiplying microbe”