IFN-α and IL-10 Induce the Differentiation of Human Type 1 T Regulatory Cells1

By M. Levings, R. Sangregorio, F. Galbiati, S. Squadrone, R. de Waal Malefyt, M. Roncarolo. Journal of Immunology, 2001

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Interleukin-10 Therapy—Review of a New Approach (2003, background): “The presence of IL-10 during the activation of CD4 T cells results in the development of a regulatory phenotype of these cells (Groux et al., 1997; Zeller et al., 1999; Levings et al., 2001a,b).”
Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma (2005, background): “For example, the T R 1 cells described by Roncarolo et al.(59,60) produce some IFN-γ and IL-5; however, regulatory T cells driven by immunosuppressive drugs(62,70), soluble protein or peptide antigen(57,58,61,63) produce IL-10 but not IFN-γ or IL-5.”
Type I interferon in systemic lupus erythematosus and other autoimmune diseases. (2006, neutral): “) (Levings et al., 2001).”
Type I interferon: friend or foe? (2010, background): “Type I IFN also triggers the generation of IL-10–producing regulatory T (TR1) cells that dampen both innate and adaptive resistance to infection (Dikopoulos et al., 2005; Levings et al., 2001).”