Type I interferon: friend or foe?
By G. Trinchieri. Journal of Experimental Medicine, 2010
878 citations recorded by the source corpus.
Although the role of type I interferon (IFN) in the protection against viral infections has been known and studied for decades, its role in other immunologically relevant scenarios, including bacterial infections, shock, autoimmunity, and cancer, is less well defined and potentially much more complicated.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/63dca8c62a01f83f97260e6047f8a7ac6358cbc1
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In Immunology
Citations in the corpus
- Mucosal Immunity in the Female Genital Tract, HIV/AIDS (2014, background): “IFNs are rapidly induced in the presence of viruses and bacteria [7, 32].”
- Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice (2016, neutral): “…viral infections, it has become increasingly evident that IFN-I also promotes detrimental inflammatory responses in some bacterial, fungal, and chronic virus infections through a complex array of mechanisms that tend to be pathogen specific (Carrero, 2013; McNab et al., 2015; Trinchieri, 2010).”
- The immune response in tuberculosis. (2013, background): “The type I IFN family of cytokines are perhaps best known for the induction of antiviral immunity, although they have pleiotropic effects on the broader immune response (323).”