Uptake and intracellular fate of surface-modified gold nanoparticles.

By P. Nativo, I. Prior, M. Brust. ACS Nano, 2008

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Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles (2010, background): “…been demonstrated with dendrimers (Wang et al. 2002; Kim et al. 2005d) and thiol-containing peptides in the case of gold nanoparticles (Levy et al. 2004; Nativo et al. 2008; Bastus et al. 2009), and as well with proteins binding to quantum dots by replacing MAA on the surface (Gao et al. 2002).”
Cytotoxicity and genotoxicity of silver nanoparticles in human cells. (2009, result): “Recent reports have established a similar mechanism, whereby gold nanoparticles were taken up by the cells through clathrin and caveoli mediated endocytosis.(49) The report established the influence of surface chemistry where different surface functionalization resulted in distinct uptake pathways.”
Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? (2010, neutral): “For gold nanoparticles, most of the studied nanoparticles have dimensions less than 100 nm and RME has been proposed as the primary mechanism of cellular entry (Shukla et al. 2005; Chithrani and Chan 2007; Nativo et al. 2008 ).”