Bidirectional activity-dependent morphological plasticity in hippocampal neurons.

By U. Nägerl, Nicola Eberhorn, Sidney B. Cambridge, Tobias Bonhoeffer. Neuron, 2004

622 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/6b306d5c49e7c23f5c459354e26070cb5cbfbe82

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. D. Selkoe
2. R. Malenka
3. E. Nestler
4. Kristen M. Harris
5. Jennifer N. Bourne
6. A. Citri
7. C. Lüscher
8. G. Shankar

In Cognitive Neuroscience

1. D. Selkoe
2. E. Nestler
3. C. Lüscher
4. Kristen M. Harris
5. Jennifer N. Bourne
6. G. Shankar
7. S. Russo
8. A. Citri

Citations in the corpus

• Do thin spines learn to be mushroom spines that remember? (2007, background): “Induction of LTD results in shrinkage [50] or retraction of dendritic spines [51] associated with a depolymerization of actin [52].”
• The yin and yang of neurotrophin action (2005, background): “In contrast to the spine growth that accompanies L-LTP expression, shrinkage or retraction of dendritic spines seems to be associated with LT”
• Heterosynaptic structural plasticity on local dendritic segments of hippocampal CA1 neurons (2014, background): “Several studies have established that activity-dependent spine shrinkage and elimination are associated with long-term depression (LTD) of synaptic transmission (Nagerl et al., 2004; Zhou et al., 2004), which can occur at individual dendritic spines via an input- and synapsespecific mechanism (Oh et”
• Balancing structure and function at hippocampal dendritic spines. (2008, background): “In contrast, LTD results in the depolymerization of actin and spine elongation or shrinkage of spine heads (Chen et al. 2004, Nagerl et al. 2004, Zhou et al. 2004).”
• COORDINATION OF SIZE AND NUMBER OF EXCITATORY AND INHIBITORY SYNAPSES RESULTS IN A BALANCED STRUCTURAL PLASTICITY ALONG MATURE HIPPOCAMPAL CA1 DENDRITES DURING LTP (2011, background): “, 2008) and loss of more distal or non-activated spines (Engert and Bonhoeffer, 1999; Nagerl et al., 2004; Nagerl et al., 2007; De Roo et al., 2008).”
• Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. (2008, background): “…whereas LTD induction promotes spine shrinkage and retraction (Engert and Bonhoeffer 1999; Maletic-Savatic et al. 1999; Matsuzaki et al. 2004; Nagerl et al. 2004; Zhou et al. 2004), this oligomer-induced imbalance would promote the progressive loss of dendritic spines and glutamatergic…”
• Activity-dependent structural plasticity. (2009, neutral): “…projections to prefrontal and limbic areas (Busche et al., 2002; Neddens et al., 2002; Lehmann et al., 2003; Neddens et al., 2003; Lehmann et al., 2004; Neddens et al., 2004; Lesting et al., 2005; Brummelte and Teuchert-Noodt, 2006; Brummelte et al., 2006; Busche et al., 2006; Witte et al., 2006).”
• The Addicted Synapse: Mechanisms of Synaptic and Structural Plasticity in Nucleus Accumbens (2010, background): “Stimulation protocols that induce LTD are associated with shrinkage or retraction of spines [27–29], whereas induction of LTP is associated with formation of new spines and enlargement of existing spines [27,28,30].”
• Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms (2008, background): “There is evidence that LTD is accompanied by a shrinkage in the size of dendritic spines (Nagerl et al, 2004; Zhou et al, 2004) and that this may be due to the loss of AMPARs (Hsieh et al, 2006).”
• Molecular mechanisms of dendritic spine morphogenesis. (2006, background): “LTP-inducing stimuli cause formation of new spines and enlargement of existing spines [10, 13 ,14], whereas long-term depression (LTD)-inducing stimulation is associated with shrinkage and/or retraction of spines [13‐15 ]( Figure 1). On the one hand, LTD requires both calcineurin and protein phospha”