Causes and consequences of tumour acidity and implications for treatment.

By M. Stubbs, P. Mcsheehy, J. Griffiths, C. Bashford. Molecular medicine today, 2000

705 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6b2e7940e7b32f4e01331e829dcb17191d391a0a

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Citations in the corpus

Angiogenic signaling pathways and anti-angiogenic therapy for cancer (2023, background): “2, or even lower).(62,63) Furthermore, the interstitial pressure in normal tissues is only 0–3 mmHg.”
The Smart Drug Delivery System and Its Clinical Potential (2016, background): “Many researches have focused on the design rationale of pH environment activated nanoparticles for smart DDSs [21, 26, 27, 80-82].”
Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release (2010, background): “However, due to the impaired vasculature, impaired lymphatic drainage, and elevated interstitial pressure, the excretion is retarded, and the metabolic products consequently accumulate (99).”
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. (2008, background): “Although important roles have been ascribed to protons in tumor progression (24), the biological contribution of lactate has been largely ignored.”
Acidity generated by the tumor microenvironment drives local invasion (2013, background): “*These authors contributed equally to this work Departments of (1) Cancer Imaging and Metabolism; (2) Radiology; (3) Advanced Microscopy Laboratory H Lee Moffitt Cancer Center and Research Institute; 12902 Magnolia Avenue; Tampa, Fl 33612 (4) Cancer Biology Program, Wayne State University School of ”
pH-sensitive nano-systems for drug delivery in cancer therapy. (2014, neutral): “4 (Engin et al., 1995; Stubbs et al., 2000).”
Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review (2011, background): “5 [25–27] such as in endocytic vesicles [70], lysosomes [71] or around solid tumors [72].”
The Science and Translation of Lactate Shuttle Theory. (2018, background): “As the result of constant lactate and hydrogen ion extrusion from cancer cells by ontogeneticderived MCT overexpression, the TME becomes an acidic environment, which seems to be key for carcinogenesis (Gillies et al., Cell Metabolism 27, April 3, 2018 773 2002; Stubbs et al., 2000).”
Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. (2006, background): “tumor effects of heat, weakly acidic chemotherapeutic agents, and aminolevulinic acid–mediated photodynamic therapy (29, 49, 50).”