Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review

By S. Bose, S. Tarafder. Acta Biomaterialia, 2011

882 citations recorded by the source corpus.

Calcium phosphates (CaPs) are the most widely used bone substitutes in bone tissue engineering due to their compositional similarities to bone mineral and excellent biocompatibility. In recent years, CaPs, especially hydroxyapatite and tricalcium phosphate, have attracted significant interest in simultaneous use as bone substitute and drug delivery vehicle, adding a new dimension to their application. CaPs are more biocompatible than many other ceramic and inorganic nanoparticles. Their biocompatibility and variable stoichiometry, thus surface charge density, functionality, and dissolution properties, make them suitable for both drug and growth factor delivery. CaP matrices and scaffolds have been reported to act as delivery vehicles for growth factors and drugs in bone tissue engineering. Local drug delivery in musculoskeletal disorder treatments can address some of the critical issues more effectively and efficiently than the systemic delivery. CaPs are used as coatings on metallic implants, CaP cements, and custom designed scaffolds to treat musculoskeletal disorders. This review highlights some of the current drug and growth factor delivery approaches and critical issues using CaP particles, coatings, cements, and scaffolds towards orthopedic and dental applications.

Subfields: Biomedical Engineering, Surgery

View Paper: https://www.semanticscholar.org/paper/8c59a1d94339b529f7e88bc56b538450337b6812

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. S. Bose
2. A. Bandyopadhyay
3. N. Metoki
4. Noam Eliaz

In Surgery

1. M. Roy
2. A. Bandyopadhyay
3. N. Metoki
4. Noam Eliaz
5. S. Bose

Citations in the corpus

• 3D bioactive composite scaffolds for bone tissue engineering (2017, background): “HA also has a strong compositional similarity to bone, with proven osteoinductive and osteoconductive properties allowing HA constructs to form a strong bond with surrounding bone [118,119].”
• Bone grafts: which is the ideal biomaterial? (2019, background): “For instance, Fielding, Bandyopadhyay, and Bose (2012) demonstrated that the addiction of silicon and zinc oxides to beta- tricalcium phosphate increased compressive strength to 2.5- fold and cell viability to 92%; however, clinical evidence is still lacking.”
• Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective (2013, neutral): “2) Synthetic (alloplastic) materials This groups contains ceramics such as bioactive glasses (88), Tricalciumphosphates (TCP) (89-90), Hydroxyapatite (HA) (91-93) and glass ionomer cements as well as Calcium Phosphate (CP) ceramics (94).”
• Ceramic Binder Jetting Additive Manufacturing: A Literature Review on Density (2020, background): “wear resistance and exceptional biocompatibility [3], they are not widely utilized because it is not cost-effective to fabricate them using conventional manufacturing technologies [4].”
• Recent advances in bone tissue engineering scaffolds (2012, background): “Commonly used drugs include Gentamicin, Vancomycin, Alendronate, Methothrexate, and Ibuprofen [69,70].”
• Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications (2017, background): “It should be kept in mind that NPs might introduce some toxicity risk in vivo through excess delivery of Ca2+ ions into cells [453].”