Broadly tuned response properties of diverse inhibitory neuron subtypes in mouse visual cortex

By Aaron Kerlin, M. Andermann, Vladimir Berezovskii, R. Clay Reid. Neuron, 2010

629 citations recorded by the source corpus.

Summary Different subtypes of GABAergic neurons in sensory cortex exhibit diverse morphology, histochemical markers, and patterns of connectivity. These subtypes likely play distinct roles in cortical function, but their in vivo response properties remain unclear. We used in vivo calcium imaging, combined with immunohistochemical and genetic labels, to record visual responses in excitatory neurons and up to three distinct subtypes of GABAergic neurons (immunoreactive for parvalbumin, somatostatin, or vasoactive intestinal peptide) in layer 2/3 of mouse visual cortex. Excitatory neurons had sharp response selectivity for stimulus orientation and spatial frequency, while all GABAergic subtypes had broader selectivity. Further, bias in the responses of GABAergic neurons toward particular orientations or spatial frequencies tended to reflect net biases of the surrounding neurons. These results suggest that the sensory responses of layer 2/3 GABAergic neurons reflect the pooled activity of the surrounding population – a principle that may generalize across species and sensory modalities.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/6adde3bc49de304c18dd4013d96f823f8872d81d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

In Sensory Systems

Citations in the corpus

Parvalbumin-Expressing Interneurons Linearly Transform Cortical Responses to Visual Stimuli (2012, background): “PV cells are known to inhibit the somatic and perisomatic compartments of Pyr cells (Kawaguchi and Kubota, 1997), appear to respond less selectively to specific sensory stimulus features as compared to Pyr cells (Sohya et al., 2007; Niell and Stryker, 2008; Kerlin et al., 2010; Cardin et al., 2007),”
Sensitive red protein calcium indicators for imaging neural activity (2016, methodology): “The fluorescence time course was measured by averaging all pixels within the ROI, after correction for neuropil contamination (Kerlin et al., 2010).”
How Inhibition Shapes Cortical Activity (2011, neutral): “…(Cardin et al., 2007; Runyan et al., 2010), while in others cortical inhibitory neurons appear to be less sharply tuned than principal cells (Figure 6; Kameyama et al., 2010; Kerlin et al., 2010; Liu et al., 2009; Niell and Stryker, 2008; Poo and Isaacson, 2009; Sohya et al., 2007; Swadlow, 1988).”
Fast and sensitive GCaMP calcium indicators for imaging neural populations (2021, neutral): “05) and comparable to 8m (84[32-165] ms) and XCaMP-Gf (91[48-155] ms) (Fig.”
A large field of view two-photon mesoscope with subcellular resolution for in vivo imaging (2016, methodology): “Calcium imaging samples activity of all labeled neurons in an imaging volume and can readily be combined with visualization of cell type markers to analyze activity in specific cell types, the nodes of neural circuits (Kerlin et al. 2010, Fu et al. 2014, Peron et al. 2015a).”
Receptive field formation by interacting excitatory and inhibitory synaptic plasticity (2016, background): “…that inhibitory inputs with a stimulus tuning that is finite but broader than their excitatory counterparts – as is encountered, e.g., in visual cortex (Kerlin et al., 2010; Hofer et al., 2011) – could support both the formation of a receptive field and an (albeit degraded) detailed balance.”
Dense, Unspecific Connectivity of Neocortical Parvalbumin-Positive Interneurons: A Canonical Microcircuit for Inhibition? (2011, background): “…outputs, interneurons in layer 2/3 of visual cortex are broadly tuned to the orientation of a stimulus (Sohya et al., 2007; Niell and Stryker, 2008; Kerlin et al., 2010; Ma et al., 2010; Zariwala et al., 2011), although some PV interneurons in the more superficial part of layer 2/3 appear to be…”