Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease
By Jin Xu, S. Kao, F. Lee, Weihong Song, Lee‐way Jin, B. Yankner. Nature Medicine, 2002
766 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Neurology
View Paper: https://www.semanticscholar.org/paper/6ad73276fbf4bc72b25b54894ce5135a48899758
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In Cellular and Molecular Neuroscience
In Neurology
- Valina L. Dawson
- T. Dawson
- S. Przedborski
- Vladimir N Uversky
- W. Dauer
- H. Ko
- Mark P. Mattson
- D. Selkoe
Citations in the corpus
- Parkinson's Disease Mechanisms and Models (2003, background): “…intoxication, Bax, a expression of mutant -synuclein in cell cultures may potent PCD agonist and member of the Bcl-2 family, is promote apoptosis (Xu et al., 2002), and cytochrome c upregulated in SNpc dopaminergic neurons (Vila et al., has been reported to stimulate in vitro aggregation of…”
- Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease (2019, background): “…the accumulation of pathogenic PD‐linked proteins (α‐sy‐ nuclein), deficiency of protective PD‐linked proteins (DJ‐1), or the incorporation of PD‐linked mutations (SNCA) similarly result in ROS‐ dependent apoptosis in cultured human or rat dopaminergic neurons (Kim et al., 2005; Xu et al., 2002).”
- Α-synuclein misfolding and Parkinson's disease. (2012, background): “synphilin [315–317], 14-3-3 protein [109, 318], prolyl-isomerase, Pin1 [319], αB-crystallin [320], different PKC isozymes, BAD, ERK [318, 321], Rab5A [322], ELK-1/ERK-2 complex [323], ERK-1/2, p38MAPK, and SAPK/JNK mitogen activated kinases (MAPKs) [324], Aβ, [325–327], MAP1B [328], heterodimeric tu”
- Oxidative stress and nitration in neurodegeneration: cause, effect, or association? (2003, background): “Support for the possibility that oxidative processes are the link between dopamine toxicity and α-synuclein is provided by recent observations that expression of α-synuclein predisposes cells to dopamine toxicity and that oxidants and nitrating agents generated by dopamine promote α-synuclein aggreg”
- Molecular pathophysiology of Parkinson's disease. (2005, background): “R : parkin - associated endothelin receptor - like receptor PINK1 : PTEN - induced putative kinase 1 ROS : reactive oxygen species SNc : substantia nigra pars compacta UCH - L1 : ubiquitin carboxyl - terminal hydrolase L1 UPS : ubiquitin - proteasome system observations .”
- The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. (2003, unknown): “Since many of the ubiquitin recycling ( SYN in the case of PD, ataxins in the case of SCAs, enzymes have redundant function, it was important to and Huntingtin in the case of HD) that are responsible find whether the activity of UCH-L1 is complemented for their toxicity (for SYN, see, for example, P”