DNA methylation controls Foxp3 gene expression

By J. Polansky, Karsten Kretschmer, Jennifer Freyer, S. Floess, A. Garbe, U. Baron, S. Olek, A. Hamann, H. von Boehmer, J. Huehn. European Journal of Immunology, 2008

824 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6a870d33ded8891310b6d71b6f90eaa1c6897fd1

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Citations in the corpus

Regulatory T Cells and Foxp3 (2011, background): “peripheral T cells stimulated in the presence of TGFb (68).”
T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. (2012, background): “Several groups have demonstrated that specific DNA demethylation and histone modifications of the Foxp3 gene occur in Treg cells, and that demethylation of the Foxp3 conserved noncoding sequence 2 (CNS2) region is important for inducing or stabilizing Foxp3 expression (Kim and Leonard, 2007; Polansk”
Development and maintenance of regulatory T cells. (2013, background): “…is a substantial amount of data indicating that DNA methylation status, especially at the Foxp3 CNS2 locus, is similar between thymic Treg cells and in-vivoinduced iTreg cells but different between in-vivo-induced iTreg cells and in-vitro-induced cells (Ohkura et al., 2012; Polansky et al., 2008).”
Foxp3 instability leads to the generation of pathogenic memory T cells in vivo (2009, positive): “…locus is a primary control mechanism of Foxp3 expression in mouse CD4 + T cells, as 90% of the CpGs in the examined intron of Foxp3 − naive CD4 + T cells were >90% methylated, whereas the CpGs in this intron were fully un-methylated in thymus-derived nT reg and in vivo generated aT reg 18– 20.”
TGF-β Activation and Function in Immunity (2013, neutral): “and display a demethylated TSDR region (72).”
Control of regulatory T cell lineage commitment and maintenance (2009, background): “Consistent with this idea, pharmacologic inhibition, knockdown, or ablation of the Dnmt1 gene and resultant CpG motif demethylation substantially increases both induction and stability of Foxp3 expression (Kim and Leonard, 2007; Polansky et al., 2008; Josefowicz et al., 2009).”
Regulatory T Cells and Human Disease. (2020, background): “It is, however, not induced in iTregs, which consequently show unstable FoxP3 expression (41, 42).”
Regulatory T Cells: Mechanisms of Differentiation and Function (2012, background): “In agreement with this hypothesis, knockdown, pharmacologic inhibition, or ablation of the Dnmt1 gene and resultant CpG motif demethylation increases both the induction and, critically, the stability of Foxp3 expression (62, 65, 70).”
Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo (2012, background): “Importantly, unlike in the in vitro induced cells, in vivo generated iT reg cells exhibited a demethylated Foxp3 T reg cell–specific demethylation region (TSDR; Polansky et al., 2008).”