Aneuploidy acts both oncogenically and as a tumor suppressor.
By Beth A. Weaver, Alain D. Silk, C. Montagna, P. Verdier-Pinard, D. Cleveland. Cancer Cell, 2007
768 citations recorded by the source corpus.
Subfields: Cell Biology, Genetics, Plant Science
View Paper: https://www.semanticscholar.org/paper/6a211e34025779b821f1db5e702afdd69a1815ec
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In Cell Biology
- Marcos Malumbres
- D. Cleveland
- A. Holland
- M. Barbacid
- D. Pellman
- Hongtao Yu
- Xuelian Luo
- Stephen J. Elledge
In Genetics
In Plant Science
Citations in the corpus
- Cell cycle, CDKs and cancer: a changing paradigm (2009, background): “Indeed, CIN itself, and perhaps GIN, may inhibit tumour growth, probably owing to inefficient cell proliferation or induction of apoptosi”
- Cellular senescence in cancer and aging. (2007, unknown): “Organismal aging is accompanied by significant increases in DNA mutations (Vijg, 2000), DNA oxidation (Hamilton et al., 2001), chromosome losses (Rehen et al., 2005; Weaver et al., 2007), and telomereindependent γH2AX foci (Sedelnikova et al., 2004).”
- Protein Metamorphosis: The Two-State Behavior of Mad2 (2008, background): “N IH -PA Author M anuscript N IH -PA Author M anuscript 2004; Jeganathan et al., 2007; Michel et al., 2001; Weaver et al., 2007).”
- A Mechanism Linking Extra Centrosomes to Chromosomal Instability (2009, methodology): “the four individual probes we used (6, 8, 7, 11).”
- Boveri revisited: Chromosomal instability, aneuploidy and tumorigenesis (2009, background): “Specifically, mice that are heterozygous for Mad1 and Mad2 develop benign lung tumours, whereas CenpE heterozygous animals show an increased incidence of benign lung tumours and splenic lymphoma”
- Causes and consequences of aneuploidy in cancer (2012, background): “A long-standing debate has centred on whether the widespread aneuploidy that is observed in cancers is a cause or a consequence of cance”
- Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy (2017, background): “A plausible explanation for this observation is that frequently selected focal SCNAs contain the optimal chromosomal segments for promotion of cell proliferation; in contrast, arm-level events are less optimized with respect to which genes are altered, and the gene dosage changes of an entire arm or”