Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy

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Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features (2017, neutral): “Variable Training set (n=225) Validation Set (n=131) TCGA set (n=190) Median age (IQR) 66 (61-72) 66 (55-71) 62 (52-70) Gender, male (%) 178 (79) 96 (73) 123 (65) Etiology (%) Hepatitis C 101 (46) 64 (50) N/A Hepatitis B 48 (21) 39 (30) N/A Alcohol 33 (15) 6 (5) N/A Others 38 (17) 19 (15) Child-Pugh”
Molecular Determinants of Response to Anti-Programmed Cell Death (PD)-1 and Anti-Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non-Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing. (2018, background): “Despite this inverse association, FGA and TMB were modestly but positively associated with each other, consistent with a previous report.(29) Given the growing concordance”
Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal (2018, positive): “Chromosome-level alterations that simultaneously affect the expression of 100s of genes can support the complex metastatic cascade by altering many functional phenotypes (Santaguida and Amon, 2015) and potentially by impacting immune evasion (Davoli et al., 2017).”